2az2: Difference between revisions

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[[Image:2az2.gif|left|200px]]
{{Seed}}
[[Image:2az2.png|left|200px]]


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{{STRUCTURE_2az2|  PDB=2az2  |  SCENE=  }}  
{{STRUCTURE_2az2|  PDB=2az2  |  SCENE=  }}  


'''Flock House virus B2-dsRNA Complex (P4122)'''
===Flock House virus B2-dsRNA Complex (P4122)===




==Overview==
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As a counter-defense against antiviral RNA silencing during infection, the insect Flock House virus (FHV) expresses the silencing suppressor protein B2. Biochemical experiments show that B2 binds to double-stranded RNA (dsRNA) without regard to length and inhibits cleavage of dsRNA by Dicer in vitro. A cocrystal structure reveals that a B2 dimer forms a four-helix bundle that binds to one face of an A-form RNA duplex independently of sequence. These results suggest that B2 blocks both cleavage of the FHV genome by Dicer and incorporation of FHV small interfering RNAs into the RNA-induced silencing complex.
The line below this paragraph, {{ABSTRACT_PUBMED_16228003}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_16228003}}


==About this Structure==
==About this Structure==
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[[Category: Four-helix bundle]]
[[Category: Four-helix bundle]]
[[Category: Protein-rna complex]]
[[Category: Protein-rna complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 19:39:02 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 10:58:46 2008''
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