2b1o: Difference between revisions

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[[Image:2b1o.gif|left|200px]]
{{Seed}}
[[Image:2b1o.png|left|200px]]


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{{STRUCTURE_2b1o|  PDB=2b1o  |  SCENE=  }}  
{{STRUCTURE_2b1o|  PDB=2b1o  |  SCENE=  }}  


'''Solution Structure of Ca2+-bound DdCAD-1'''
===Solution Structure of Ca2+-bound DdCAD-1===




==Overview==
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DdCAD-1 is a novel Ca(2+)-dependent cell adhesion molecule that lacks a hydrophobic signal peptide and a transmembrane domain. DdCAD-1 is expressed by the social amoeba Dictyostelium discoideum at the onset of development. It is synthesized as a soluble protein and then transported to the plasma membrane by contractile vacuoles. Here we describe the novel features of the solution structures of Ca(2+)-free and Ca(2+)-bound monomeric DdCAD-1. DdCAD-1 contains two beta-sandwich domains, belonging to the betagamma-crystallin and immunoglobulin fold classes, respectively. Whereas the N-terminal domain has a major role in homophilic binding, the C-terminal domain tethers the protein to the cell membrane. From structural and mutational analyses, we propose a model for the Ca(2+)-bound DdCAD-1 dimer as a basis for understanding DdCAD-1-mediated cell-cell adhesion at the molecular level. Our results provide new insights into Ca(2+)-dependent mechanisms for cell-cell adhesion.
The line below this paragraph, {{ABSTRACT_PUBMED_17057715}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17057715 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17057715}}


==About this Structure==
==About this Structure==
2B1O is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B1O OCA].  
2B1O is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B1O OCA].  


==Reference==
==Reference==
Solution structures of the adhesion molecule DdCAD-1 reveal new insights into Ca(2+)-dependent cell-cell adhesion., Lin Z, Sriskanthadevan S, Huang H, Siu CH, Yang D, Nat Struct Mol Biol. 2006 Nov;13(11):1016-22. Epub 2006 Oct 22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17057715 17057715]
Solution structures of the adhesion molecule DdCAD-1 reveal new insights into Ca(2+)-dependent cell-cell adhesion., Lin Z, Sriskanthadevan S, Huang H, Siu CH, Yang D, Nat Struct Mol Biol. 2006 Nov;13(11):1016-22. Epub 2006 Oct 22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17057715 17057715]
(1)H, (13)C and (15)N resonance assignments of Ca(2+)-free DdCAD-1: a Ca(2+)-dependent cell-cell adhesion molecule., Lin Z, Huang H, Siu CH, Yang D, J Biomol NMR. 2004 Nov;30(3):375-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15756470 15756470]
[[Category: Dictyostelium discoideum]]
[[Category: Dictyostelium discoideum]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Ddcad-1]]
[[Category: Ddcad-1]]
[[Category: Nmr]]
[[Category: Nmr]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 19:44:36 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:34:17 2008''

Revision as of 06:34, 28 July 2008

File:2b1o.png

Template:STRUCTURE 2b1o

Solution Structure of Ca2+-bound DdCAD-1

Template:ABSTRACT PUBMED 17057715

About this Structure

2B1O is a Single protein structure of sequence from Dictyostelium discoideum. Full experimental information is available from OCA.

Reference

Solution structures of the adhesion molecule DdCAD-1 reveal new insights into Ca(2+)-dependent cell-cell adhesion., Lin Z, Sriskanthadevan S, Huang H, Siu CH, Yang D, Nat Struct Mol Biol. 2006 Nov;13(11):1016-22. Epub 2006 Oct 22. PMID:17057715

(1)H, (13)C and (15)N resonance assignments of Ca(2+)-free DdCAD-1: a Ca(2+)-dependent cell-cell adhesion molecule., Lin Z, Huang H, Siu CH, Yang D, J Biomol NMR. 2004 Nov;30(3):375-6. PMID:15756470

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