2b1p: Difference between revisions

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[[Image:2b1p.gif|left|200px]]
{{Seed}}
[[Image:2b1p.png|left|200px]]


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{{STRUCTURE_2b1p|  PDB=2b1p  |  SCENE=  }}  
{{STRUCTURE_2b1p|  PDB=2b1p  |  SCENE=  }}  


'''inhibitor complex of JNK3'''
===inhibitor complex of JNK3===




==Overview==
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The structure-based design and synthesis of a new series of c-Jun N-terminal kinase-3 inhibitors with selectivity against JNK1 and p38alpha is reported. The novel series of substituted 6-anilinoindazoles were designed based on a combination of hits from high throughput screening and X-ray crystal structure information of the compounds crystallized into the JNK3 ATP binding active site.
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{{ABSTRACT_PUBMED_16140012}}


==About this Structure==
==About this Structure==
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[[Category: Enzyme-inhibitor complex]]
[[Category: Enzyme-inhibitor complex]]
[[Category: Kinase inhibitor]]
[[Category: Kinase inhibitor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 19:44:38 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:36:11 2008''

Revision as of 19:36, 27 July 2008

File:2b1p.png

Template:STRUCTURE 2b1p

inhibitor complex of JNK3

Template:ABSTRACT PUBMED 16140012

About this Structure

2B1P is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Design and synthesis of 6-anilinoindazoles as selective inhibitors of c-Jun N-terminal kinase-3., Swahn BM, Huerta F, Kallin E, Malmstrom J, Weigelt T, Viklund J, Womack P, Xue Y, Ohberg L, Bioorg Med Chem Lett. 2005 Nov 15;15(22):5095-9. PMID:16140012

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