2b3e: Difference between revisions

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[[Image:2b3e.gif|left|200px]]
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{{STRUCTURE_2b3e|  PDB=2b3e  |  SCENE=  }}  
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'''Crystal structure of DB819-D(CGCGAATTCGCG)2 complex.'''
===Crystal structure of DB819-D(CGCGAATTCGCG)2 complex.===




==Overview==
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The crystal structure of the DNA minor groove biphenyl benzimidazole diamidine ligand DB819 has been determined, bound to the DNA sequence d(CGCGAATTCGCG)(2), at a resolution of 1.36 Angstrom. Conditions for reliable in silico docking that reproduce the observed position of the ligand in the minor groove have been determined.
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{{ABSTRACT_PUBMED_16263285}}


==About this Structure==
==About this Structure==
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[[Category: Minor groove]]
[[Category: Minor groove]]
[[Category: Nucleic acid]]
[[Category: Nucleic acid]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 19:48:12 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:43:17 2008''

Revision as of 08:43, 28 July 2008

File:2b3e.png

Template:STRUCTURE 2b3e

Crystal structure of DB819-D(CGCGAATTCGCG)2 complex.

Template:ABSTRACT PUBMED 16263285

About this Structure

Full crystallographic information is available from OCA.

Reference

Targeting the DNA minor groove with fused ring dicationic compounds: comparison of in silico screening and a high-resolution crystal structure., Campbell NH, Evans DA, Lee MP, Parkinson GN, Neidle S, Bioorg Med Chem Lett. 2006 Jan 1;16(1):15-9. Epub 2005 Nov 2. PMID:16263285

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