2b3o: Difference between revisions

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[[Image:2b3o.gif|left|200px]]
{{Seed}}
[[Image:2b3o.png|left|200px]]


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{{STRUCTURE_2b3o|  PDB=2b3o  |  SCENE=  }}  
{{STRUCTURE_2b3o|  PDB=2b3o  |  SCENE=  }}  


'''Crystal structure of human tyrosine phosphatase SHP-1'''
===Crystal structure of human tyrosine phosphatase SHP-1===




==Overview==
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SHP-1 is a cytosolic protein-tyrosine phosphatase that behaves as a negative regulator in eukaryotic cellular signaling pathways. To understand its regulatory mechanism, we have determined the crystal structure of the C-terminal truncated human SHP-1 in the inactive conformation at 2.8-A resolution and refined the structure to a crystallographic R-factor of 24.0%. The three-dimensional structure shows that the ligand-free SHP-1 has an auto-inhibited conformation. Its N-SH2 domain blocks the catalytic domain and keeps the enzyme in the inactive conformation, which supports that the phosphatase activity of SHP-1 is primarily regulated by the N-SH2 domain. In addition, the C-SH2 domain of SHP-1 has a different orientation from and is more flexible than that of SHP-2, which enables us to propose an enzymatic activation mechanism in which the C-SH2 domains of SHPs could be involved in searching for phosphotyrosine activators.
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{{ABSTRACT_PUBMED_12482860}}


==About this Structure==
==About this Structure==
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[[Category: Shp-1]]
[[Category: Shp-1]]
[[Category: Signaling]]
[[Category: Signaling]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 19:48:44 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:51:02 2008''

Revision as of 13:51, 28 July 2008

File:2b3o.png

Template:STRUCTURE 2b3o

Crystal structure of human tyrosine phosphatase SHP-1

Template:ABSTRACT PUBMED 12482860

About this Structure

2B3O is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human protein-tyrosine phosphatase SHP-1., Yang J, Liu L, He D, Song X, Liang X, Zhao ZJ, Zhou GW, J Biol Chem. 2003 Feb 21;278(8):6516-20. Epub 2002 Dec 13. PMID:12482860

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