2b4c: Difference between revisions

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[[Image:2b4c.gif|left|200px]]
{{Seed}}
[[Image:2b4c.png|left|200px]]


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{{STRUCTURE_2b4c|  PDB=2b4c  |  SCENE=  }}  
{{STRUCTURE_2b4c|  PDB=2b4c  |  SCENE=  }}  


'''Crystal structure of HIV-1 JR-FL gp120 core protein containing the third variable region (V3) complexed with CD4 and the X5 antibody'''
===Crystal structure of HIV-1 JR-FL gp120 core protein containing the third variable region (V3) complexed with CD4 and the X5 antibody===




==Overview==
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The third variable region (V3) of the HIV-1 gp120 envelope glycoprotein is immunodominant and contains features essential for coreceptor binding. We determined the structure of V3 in the context of an HIV-1 gp120 core complexed to the CD4 receptor and to the X5 antibody at 3.5 angstrom resolution. Binding of gp120 to cell-surface CD4 would position V3 so that its coreceptor-binding tip protrudes 30 angstroms from the core toward the target cell membrane. The extended nature and antibody accessibility of V3 explain its immunodominance. Together, the results provide a structural rationale for the role of V3 in HIV entry and neutralization.
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(as it appears on PubMed at http://www.pubmed.gov), where 16284180 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16284180}}
 
==Disease==
Known disease associated with this structure: CD4 lymphocyte deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=186940 186940]], Lupus erythematosus, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=186940 186940]]


==About this Structure==
==About this Structure==
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[[Category: V3]]
[[Category: V3]]
[[Category: X5]]
[[Category: X5]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 19:50:17 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:45:59 2008''

Revision as of 05:46, 29 July 2008

File:2b4c.png

Template:STRUCTURE 2b4c

Crystal structure of HIV-1 JR-FL gp120 core protein containing the third variable region (V3) complexed with CD4 and the X5 antibody

Template:ABSTRACT PUBMED 16284180

Disease

Known disease associated with this structure: CD4 lymphocyte deficiency OMIM:[186940], Lupus erythematosus, susceptibility to OMIM:[186940]

About this Structure

2B4C is a Protein complex structure of sequences from Homo sapiens and Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Structure of a V3-containing HIV-1 gp120 core., Huang CC, Tang M, Zhang MY, Majeed S, Montabana E, Stanfield RL, Dimitrov DS, Korber B, Sodroski J, Wilson IA, Wyatt R, Kwong PD, Science. 2005 Nov 11;310(5750):1025-8. PMID:16284180

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