2b6p: Difference between revisions

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[[Image:2b6p.gif|left|200px]]
{{Seed}}
[[Image:2b6p.png|left|200px]]


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{{STRUCTURE_2b6p|  PDB=2b6p  |  SCENE=  }}  
{{STRUCTURE_2b6p|  PDB=2b6p  |  SCENE=  }}  


'''X-ray structure of lens Aquaporin-0 (AQP0) (lens MIP) in an open pore state'''
===X-ray structure of lens Aquaporin-0 (AQP0) (lens MIP) in an open pore state===




==Overview==
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Lens-specific aquaporin-0 (AQP0) functions as a specific water pore and forms the thin junctions between fibre cells. Here we describe a 1.9 A resolution structure of junctional AQP0, determined by electron crystallography of double-layered two-dimensional crystals. Comparison of junctional and non-junctional AQP0 structures shows that junction formation depends on a conformational switch in an extracellular loop, which may result from cleavage of the cytoplasmic amino and carboxy termini. In the centre of the water pathway, the closed pore in junctional AQP0 retains only three water molecules, which are too widely spaced to form hydrogen bonds with each other. Packing interactions between AQP0 tetramers in the crystalline array are mediated by lipid molecules, which assume preferred conformations. We were therefore able to build an atomic model for the lipid bilayer surrounding the AQP0 tetramers, and we describe lipid-protein interactions.
The line below this paragraph, {{ABSTRACT_PUBMED_16319884}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_16319884}}


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Lipid-protein interactions in double-layered two-dimensional AQP0 crystals., Gonen T, Cheng Y, Sliz P, Hiroaki Y, Fujiyoshi Y, Harrison SC, Walz T, Nature. 2005 Dec 1;438(7068):633-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16319884 16319884]
Lipid-protein interactions in double-layered two-dimensional AQP0 crystals., Gonen T, Cheng Y, Sliz P, Hiroaki Y, Fujiyoshi Y, Harrison SC, Walz T, Nature. 2005 Dec 1;438(7068):633-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16319884 16319884]
The channel architecture of aquaporin 0 at a 2.2-A resolution., Harries WE, Akhavan D, Miercke LJ, Khademi S, Stroud RM, Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):14045-50. Epub 2004 Sep 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15377788 15377788]
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Membrane protein;]]
[[Category: Membrane protein;]]
[[Category: Open water pore]]
[[Category: Open water pore]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 19:55:31 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:29:24 2008''

Revision as of 23:29, 28 July 2008

File:2b6p.png

Template:STRUCTURE 2b6p

X-ray structure of lens Aquaporin-0 (AQP0) (lens MIP) in an open pore state

Template:ABSTRACT PUBMED 16319884

About this Structure

2B6P is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Lipid-protein interactions in double-layered two-dimensional AQP0 crystals., Gonen T, Cheng Y, Sliz P, Hiroaki Y, Fujiyoshi Y, Harrison SC, Walz T, Nature. 2005 Dec 1;438(7068):633-8. PMID:16319884

The channel architecture of aquaporin 0 at a 2.2-A resolution., Harries WE, Akhavan D, Miercke LJ, Khademi S, Stroud RM, Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):14045-50. Epub 2004 Sep 17. PMID:15377788

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