2b7f: Difference between revisions

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[[Image:2b7f.gif|left|200px]]
{{Seed}}
[[Image:2b7f.png|left|200px]]


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{{STRUCTURE_2b7f|  PDB=2b7f  |  SCENE=  }}  
{{STRUCTURE_2b7f|  PDB=2b7f  |  SCENE=  }}  


'''Crystal structure of human T-cell leukemia virus protease, a novel target for anti-cancer design'''
===Crystal structure of human T-cell leukemia virus protease, a novel target for anti-cancer design===




==Overview==
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The successful development of a number of HIV-1 protease (PR) inhibitors for the treatment of AIDS has validated the utilization of retroviral PRs as drug targets and necessitated their detailed structural study. Here we report the structure of a complex of human T cell leukemia virus type 1 (HTLV-1) PR with a substrate-based inhibitor bound in subsites P5 through P5'. Although HTLV-1 PR exhibits an overall fold similar to other retroviral PRs, significant structural differences are present in several loop areas, which include the functionally important flaps, previously considered to be structurally highly conserved. Potential key residues responsible for the resistance of HTLV-1 PR to anti-HIV drugs are identified. We expect that the knowledge accumulated during the development of anti-HIV drugs, particularly in overcoming drug resistance, will help in designing a novel class of antileukemia drugs targeting HTLV-1 PR and in predicting their drug-resistance profile. The structure presented here can be used as a starting point for the development of such anticancer therapies.
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{{ABSTRACT_PUBMED_16352712}}


==About this Structure==
==About this Structure==
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[[Category: Wlodawer, A.]]
[[Category: Wlodawer, A.]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 19:56:59 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:33:50 2008''

Revision as of 13:33, 27 July 2008

File:2b7f.png

Template:STRUCTURE 2b7f

Crystal structure of human T-cell leukemia virus protease, a novel target for anti-cancer design

Template:ABSTRACT PUBMED 16352712

About this Structure

2B7F is a Single protein structure of sequence from Human t-cell leukemia virus type i. Full crystallographic information is available from OCA.

Reference

Crystal structure of human T cell leukemia virus protease, a novel target for anticancer drug design., Li M, Laco GS, Jaskolski M, Rozycki J, Alexandratos J, Wlodawer A, Gustchina A, Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18332-7. Epub 2005 Dec 13. PMID:16352712

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