2bam: Difference between revisions

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[[Image:2bam.gif|left|200px]]
{{Seed}}
[[Image:2bam.png|left|200px]]


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{{STRUCTURE_2bam|  PDB=2bam  |  SCENE=  }}  
{{STRUCTURE_2bam|  PDB=2bam  |  SCENE=  }}  


'''RESTRICTION ENDONUCLEASE BAMHI COMPLEX WITH DNA AND CALCIUM IONS (PRE-REACTIVE COMPLEX).'''
===RESTRICTION ENDONUCLEASE BAMHI COMPLEX WITH DNA AND CALCIUM IONS (PRE-REACTIVE COMPLEX).===




==Overview==
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Type II restriction enzymes are characterized by their remarkable specificity and simplicity. They require only divalent metals (such as Mg2+ or Mn2+) as cofactors to catalyze the hydrolysis of DNA. However, most of the structural work on endonucleases has been performed in the absence of metals, leaving unanswered questions about their mechanisms of DNA cleavage. Here we report structures of the endonuclease BamHI-DNA complex, determined in the presence of Mn2+ and Ca2+, that describe the enzyme at different stages of catalysis. Overall, the results support a two-metal mechanism of DNA cleavage for BamHI which is distinct from that of EcoRV.
The line below this paragraph, {{ABSTRACT_PUBMED_9783752}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9783752 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9783752}}


==About this Structure==
==About this Structure==
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[[Category: Nuclease]]
[[Category: Nuclease]]
[[Category: Phosphodiesterase]]
[[Category: Phosphodiesterase]]
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