2bht: Difference between revisions

Line 1:

[[Image:2bht.~~gif~~|left|200px]]

[[Image:2bht.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~CRYSTAL STRUCTURE OF O-ACETYLSERINE SULFHYDRYLASE B~~'''~~

===CRYSTAL STRUCTURE OF O-ACETYLSERINE SULFHYDRYLASE B===

~~==Overview==~~

<!--

The ~~enzyme O-acetylserine sulfhydrylase participates in~~ the ~~biosynthesis of l-cysteine in bacteria and plants. The structure of isoenzyme B~~ (~~CysM) from Escherichia coli was established in a hexagonal crystal form~~ at 2.~~7 A resolution (wild-type) and in a merohedrally twinned tetragonal crystal form at 2~~.~~1 A resolution (surface mutant~~)~~. Structural superpositions revealed the variations with respect to isoenzyme A (CysK) and explained~~ the ~~different substrate specificities~~. ~~A geometric model of the reaction catalyzed by CysM is proposed. Both isoenzymes are used for the production of l~~-amino acid derivatives as building blocks for the synthesis of peptides and peptidomimetic drugs. Since the structure of CysM revealed a remarkable main chain variation at the active center, it constitutes a further starting point for engineering mutants with novel substrate specificities.

The line below this paragraph, {{ABSTRACT_PUBMED_15952768}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 15952768 is the PubMed ID number.

-->

==About this Structure==

Line 32:

Line 36:

[[Category: Pyridoxal-5'-phosphate]]

[[Category: Transferase]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 20~~:18:32 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:15:15 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:2bht.gif|left|200px]]
+{{Seed}}
+[[Image:2bht.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_2bht|  PDB=2bht  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF O-ACETYLSERINE SULFHYDRYLASE B'''
+===CRYSTAL STRUCTURE OF O-ACETYLSERINE SULFHYDRYLASE B===
-==Overview==
+<!--
-The enzyme O-acetylserine sulfhydrylase participates in the biosynthesis of l-cysteine in bacteria and plants. The structure of isoenzyme B (CysM) from Escherichia coli was established in a hexagonal crystal form at 2.7 A resolution (wild-type) and in a merohedrally twinned tetragonal crystal form at 2.1 A resolution (surface mutant). Structural superpositions revealed the variations with respect to isoenzyme A (CysK) and explained the different substrate specificities. A geometric model of the reaction catalyzed by CysM is proposed. Both isoenzymes are used for the production of l-amino acid derivatives as building blocks for the synthesis of peptides and peptidomimetic drugs. Since the structure of CysM revealed a remarkable main chain variation at the active center, it constitutes a further starting point for engineering mutants with novel substrate specificities.
+The line below this paragraph, {{ABSTRACT_PUBMED_15952768}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15952768 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15952768}}
 ==About this Structure==
@@ Line 32: / Line 36: @@
 [[Category: Pyridoxal-5'-phosphate]]
 [[Category: Transferase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 20:18:32 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:15:15 2008''