2f1g: Difference between revisions
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New page: left|200px<br /> <applet load="2f1g" size="450" color="white" frame="true" align="right" spinBox="true" caption="2f1g, resolution 1.90Å" /> '''Cathepsin S in comp... |
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[[Image:2f1g.gif|left|200px]]<br /> | [[Image:2f1g.gif|left|200px]]<br /><applet load="2f1g" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="2f1g" size=" | |||
caption="2f1g, resolution 1.90Å" /> | caption="2f1g, resolution 1.90Å" /> | ||
'''Cathepsin S in complex with non-covalent 2-(Benzoxazol-2-ylamino)-acetamide'''<br /> | '''Cathepsin S in complex with non-covalent 2-(Benzoxazol-2-ylamino)-acetamide'''<br /> | ||
==Overview== | ==Overview== | ||
A series of N(alpha)-2-benzoxazolyl-alpha-amino | A series of N(alpha)-2-benzoxazolyl-alpha-amino acid-(arylaminoethyl)amides were identified as potent, selective, and noncovalent inhibitors of cathepsin S. Structure-activity relationships including strategies for modulating the selectivities among cathepsins S, K, and L, and in vivo pharmacokinetics are discussed. A X-ray structure of compound 3 bound to the active site of cathepsin S is also reported. | ||
==About this Structure== | ==About this Structure== | ||
2F1G is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with GNF and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] Full crystallographic information is available from [http:// | 2F1G is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=GNF:'>GNF</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F1G OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Clark, K.]] | [[Category: Clark, K.]] | ||
[[Category: Harris, J | [[Category: Harris, J L.]] | ||
[[Category: Hornsby, M.]] | [[Category: Hornsby, M.]] | ||
[[Category: Karenewsky, D | [[Category: Karenewsky, D S.]] | ||
[[Category: Kulathila, R.]] | [[Category: Kulathila, R.]] | ||
[[Category: Lesley, S | [[Category: Lesley, S A.]] | ||
[[Category: Spraggon, G.]] | [[Category: Spraggon, G.]] | ||
[[Category: Tully, D | [[Category: Tully, D C.]] | ||
[[Category: GNF]] | [[Category: GNF]] | ||
[[Category: GOL]] | [[Category: GOL]] | ||
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[[Category: noncovalent]] | [[Category: noncovalent]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:16:43 2008'' | ||
