2bmf: Difference between revisions

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[[Image:2bmf.gif|left|200px]]
{{Seed}}
[[Image:2bmf.png|left|200px]]


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{{STRUCTURE_2bmf|  PDB=2bmf  |  SCENE=  }}  
{{STRUCTURE_2bmf|  PDB=2bmf  |  SCENE=  }}  


'''DENGUE VIRUS RNA HELICASE AT 2.4A'''
===DENGUE VIRUS RNA HELICASE AT 2.4A===




==Overview==
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Dengue fever is an important emerging public health concern, with several million viral infections occurring annually, for which no effective therapy currently exists. The NS3 protein from Dengue virus is a multifunctional protein of 69 kDa, endowed with protease, helicase, and nucleoside 5'-triphosphatase (NTPase) activities. Thus, NS3 plays an important role in viral replication and represents a very interesting target for the development of specific antiviral inhibitors. We present the structure of an enzymatically active fragment of the Dengue virus NTPase/helicase catalytic domain to 2.4 A resolution. The structure is composed of three domains, displays an asymmetric distribution of charges on its surface, and contains a tunnel large enough to accommodate single-stranded RNA. Its C-terminal domain adopts a new fold compared to the NS3 helicase of hepatitis C virus, which has interesting implications for the evolution of the Flaviviridae replication complex. A bound sulfate ion reveals residues involved in the metal-dependent NTPase catalytic mechanism. Comparison with the NS3 hepatitis C virus helicase complexed to single-stranded DNA would place the 3' single-stranded tail of a nucleic acid duplex in the tunnel that runs across the basic face of the protein. A possible model for the unwinding mechanism is proposed.
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{{ABSTRACT_PUBMED_16051821}}


==About this Structure==
==About this Structure==
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[[Category: Nucleoside triphosphatase]]
[[Category: Nucleoside triphosphatase]]
[[Category: Rna helicase]]
[[Category: Rna helicase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 20:29:43 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:09:23 2008''

Revision as of 21:09, 28 July 2008

File:2bmf.png

Template:STRUCTURE 2bmf

DENGUE VIRUS RNA HELICASE AT 2.4A

Template:ABSTRACT PUBMED 16051821

About this Structure

2BMF is a Single protein structure of sequence from Dengue virus 2. Full crystallographic information is available from OCA.

Reference

Structure of the Dengue virus helicase/nucleoside triphosphatase catalytic domain at a resolution of 2.4 A., Xu T, Sampath A, Chao A, Wen D, Nanao M, Chene P, Vasudevan SG, Lescar J, J Virol. 2005 Aug;79(16):10278-88. PMID:16051821

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