2f9b: Difference between revisions
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New page: left|200px<br /> <applet load="2f9b" size="450" color="white" frame="true" align="right" spinBox="true" caption="2f9b, resolution 2.54Å" /> '''Discovery of Novel ... |
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[[Image:2f9b.gif|left|200px]]<br /> | [[Image:2f9b.gif|left|200px]]<br /><applet load="2f9b" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="2f9b" size=" | |||
caption="2f9b, resolution 2.54Å" /> | caption="2f9b, resolution 2.54Å" /> | ||
'''Discovery of Novel Heterocyclic Factor VIIa Inhibitors'''<br /> | '''Discovery of Novel Heterocyclic Factor VIIa Inhibitors'''<br /> | ||
==Overview== | ==Overview== | ||
Structure-activity relationships and binding mode of novel heterocyclic | Structure-activity relationships and binding mode of novel heterocyclic factor VIIa inhibitors will be described. In these inhibitors, a highly basic 5-amidinoindole moiety has been successfully replaced with a less basic 5-aminopyrrolo[3,2-b]pyridine scaffold. | ||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
2F9B is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with N1H as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Coagulation_factor_VIIa Coagulation factor VIIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.21 3.4.21.21] Full crystallographic information is available from [http:// | 2F9B is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=N1H:'>N1H</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Coagulation_factor_VIIa Coagulation factor VIIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.21 3.4.21.21] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F9B OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Cabuslay, R.]] | [[Category: Cabuslay, R.]] | ||
[[Category: Hendrix, J.]] | [[Category: Hendrix, J.]] | ||
[[Category: Katz, B | [[Category: Katz, B A.]] | ||
[[Category: Kolesnikov, A.]] | [[Category: Kolesnikov, A.]] | ||
[[Category: Rai, R.]] | [[Category: Rai, R.]] | ||
[[Category: Sanford, E.]] | [[Category: Sanford, E.]] | ||
[[Category: Shrader, W | [[Category: Shrader, W D.]] | ||
[[Category: Sprengeler, P | [[Category: Sprengeler, P A.]] | ||
[[Category: Stephens, R.]] | [[Category: Stephens, R.]] | ||
[[Category: Ton, T.]] | [[Category: Ton, T.]] | ||
[[Category: Torkelson, S.]] | [[Category: Torkelson, S.]] | ||
[[Category: Young, W | [[Category: Young, W B.]] | ||
[[Category: Yu, C.]] | [[Category: Yu, C.]] | ||
[[Category: N1H]] | [[Category: N1H]] | ||
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[[Category: short hydrogen bond]] | [[Category: short hydrogen bond]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:19:02 2008'' | ||
