2bqv: Difference between revisions

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[[Image:2bqv.gif|left|200px]]
{{Seed}}
[[Image:2bqv.png|left|200px]]


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{{STRUCTURE_2bqv|  PDB=2bqv  |  SCENE=  }}  
{{STRUCTURE_2bqv|  PDB=2bqv  |  SCENE=  }}  


'''HIV-1 PROTEASE IN COMPLEX WITH INHIBITOR AHA455'''
===HIV-1 PROTEASE IN COMPLEX WITH INHIBITOR AHA455===




==Overview==
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Novel HIV-1 protease inhibitors encompassing a tertiary alcohol as part of the transition-state mimicking unit have been synthesized. Variation of the P1'-P3' residues and alteration of the tertiary alcohol absolute stereochemistry afforded 10 inhibitors. High potencies for the compounds with (S)-configuration at the carbon carrying the tertiary hydroxyl group were achieved with Ki values down to 2.4 nM. X-ray crystallographic data for a representative compound in complex with HIV-1 protease are presented.
The line below this paragraph, {{ABSTRACT_PUBMED_16335934}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16335934 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16335934}}


==About this Structure==
==About this Structure==
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[[Category: Hydrolase complex]]
[[Category: Hydrolase complex]]
[[Category: Inhibitor]]
[[Category: Inhibitor]]
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