2brs: Difference between revisions

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[[Image:2brs.jpg|left|200px]]
{{Seed}}
[[Image:2brs.png|left|200px]]


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{{STRUCTURE_2brs|  PDB=2brs  |  SCENE=  }}  
{{STRUCTURE_2brs|  PDB=2brs  |  SCENE=  }}  


'''EMBP HEPARIN COMPLEX'''
===EMBP HEPARIN COMPLEX===




==Overview==
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The eosinophil major basic protein (EMBP), a constituent of the eosinophil secondary granule, is implicated in cytotoxicity and mediation of allergic disorders such as asthma. It is a member of the C-type lectin family, but lacks a Ca(2+)- and carbohydrate-binding site as seen in other members of this family. Here, we report the crystal structure of EMBP in complex with a heparin disaccharide and in the absence of Ca(2+), the first such report of any C-lectin with this sugar. We also provide direct evidence of binding of EMBP to heparin and heparin disaccharide by surface plasmon resonance. We propose that the sugars recognized by EMBP are likely to be proteoglycans such as heparin, leading to new interpretations for EMBP function.
The line below this paragraph, {{ABSTRACT_PUBMED_16245931}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16245931 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16245931}}


==About this Structure==
==About this Structure==
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[[Category: Proteoglycan]]
[[Category: Proteoglycan]]
[[Category: Signal]]
[[Category: Signal]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 20:42:30 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:24:37 2008''
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