2bs0: Difference between revisions

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[[Image:2bs0.png|left|200px]]

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~~'''~~MS2 (N87AE89K MUTANT)- VARIANT QBETA RNA HAIRPIN COMPLEX~~'''~~

===MS2 (N87AE89K MUTANT)- VARIANT QBETA RNA HAIRPIN COMPLEX===

~~==Overview==~~

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~~Sequence~~-~~specific interactions between RNA stem~~-~~loops and coat protein (CP) subunits play vital roles in~~ the ~~life cycles of~~ the ~~RNA bacteriophages, e~~.g., by allowing translational repression of their replicase cistrons and tagging their own RNA genomes for encapsidation. The CPs of bacteriophages Qbeta and MS2 each discriminate in favor of their cognate translational operators, even in the ~~presence of closely related operators from other phages in vivo~~. ~~Discrete mutations within the MS2 CP have been shown to relax this discrimination in vitro. We have determined the structures of eight complexes between such mutants and both MS2 and Qbeta stem~~-~~loops with X~~-~~ray crystallography. In conjunction with previously determined in vivo repression data, the structures enable us to propose the molecular basis for the discrimination mechanism.~~

The line below this paragraph, {{ABSTRACT_PUBMED_16531233}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 16531233 is the PubMed ID number.

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==About this Structure==

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[[Category: Virus coat protein]]

[[Category: Virus/viral protein/rna]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 20~~:43:00 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:59:04 2008''

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-[[Image:2bs0.gif|left|200px]]
+{{Seed}}
+[[Image:2bs0.png|left|200px]]
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 {{STRUCTURE_2bs0|  PDB=2bs0  |  SCENE=  }}
-'''MS2 (N87AE89K MUTANT)- VARIANT QBETA RNA HAIRPIN COMPLEX'''
+===MS2 (N87AE89K MUTANT)- VARIANT QBETA RNA HAIRPIN COMPLEX===
-==Overview==
+<!--
-Sequence-specific interactions between RNA stem-loops and coat protein (CP) subunits play vital roles in the life cycles of the RNA bacteriophages, e.g., by allowing translational repression of their replicase cistrons and tagging their own RNA genomes for encapsidation. The CPs of bacteriophages Qbeta and MS2 each discriminate in favor of their cognate translational operators, even in the presence of closely related operators from other phages in vivo. Discrete mutations within the MS2 CP have been shown to relax this discrimination in vitro. We have determined the structures of eight complexes between such mutants and both MS2 and Qbeta stem-loops with X-ray crystallography. In conjunction with previously determined in vivo repression data, the structures enable us to propose the molecular basis for the discrimination mechanism.
+The line below this paragraph, {{ABSTRACT_PUBMED_16531233}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16531233 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16531233}}
 ==About this Structure==
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 [[Category: Virus coat protein]]
 [[Category: Virus/viral protein/rna]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 20:43:00 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:59:04 2008''