2fda: Difference between revisions
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New page: left|200px<br /> <applet load="2fda" size="450" color="white" frame="true" align="right" spinBox="true" caption="2fda, resolution 2.00Å" /> '''Crystal Structure o... |
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[[Image:2fda.gif|left|200px]]<br /> | [[Image:2fda.gif|left|200px]]<br /><applet load="2fda" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="2fda" size=" | |||
caption="2fda, resolution 2.00Å" /> | caption="2fda, resolution 2.00Å" /> | ||
'''Crystal Structure of the Catalytic Domain of Human Coagulation Factor XIa in Complex with alpha-Ketothiazole Arginine Derived Ligand'''<br /> | '''Crystal Structure of the Catalytic Domain of Human Coagulation Factor XIa in Complex with alpha-Ketothiazole Arginine Derived Ligand'''<br /> | ||
==Overview== | ==Overview== | ||
Using an alpha-ketothiazole arginine moiety as a key recognition element, a series of small peptidomimetic molecules was designed and synthesized, and their co-crystal structures with factor XIa were studied in an effort | Using an alpha-ketothiazole arginine moiety as a key recognition element, a series of small peptidomimetic molecules was designed and synthesized, and their co-crystal structures with factor XIa were studied in an effort to develop smaller, less peptidic inhibitors as antithrombotic agents. | ||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
2FDA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with BCT, SO4 and 682 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Coagulation_factor_XIa Coagulation factor XIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.27 3.4.21.27] Full crystallographic information is available from [http:// | 2FDA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=BCT:'>BCT</scene>, <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=682:'>682</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Coagulation_factor_XIa Coagulation factor XIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.27 3.4.21.27] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FDA OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Abdel-Meguid, S | [[Category: Abdel-Meguid, S S.]] | ||
[[Category: Babine, R | [[Category: Babine, R E.]] | ||
[[Category: Jin, L.]] | [[Category: Jin, L.]] | ||
[[Category: Pandey, P.]] | [[Category: Pandey, P.]] | ||
[[Category: Strickler, J | [[Category: Strickler, J E.]] | ||
[[Category: Weaver, D | [[Category: Weaver, D T.]] | ||
[[Category: 682]] | [[Category: 682]] | ||
[[Category: BCT]] | [[Category: BCT]] | ||
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[[Category: inhibitor]] | [[Category: inhibitor]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:20:10 2008'' | ||
