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| [[Image:2byp.gif|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_2byp| PDB=2byp | SCENE= }} | | {{STRUCTURE_2byp| PDB=2byp | SCENE= }} |
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| '''CRYSTAL STRUCTURE OF APLYSIA CALIFORNICA ACHBP IN COMPLEX WITH ALPHA-CONOTOXIN IMI'''
| | ===CRYSTAL STRUCTURE OF APLYSIA CALIFORNICA ACHBP IN COMPLEX WITH ALPHA-CONOTOXIN IMI=== |
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| ==Overview==
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| Upon ligand binding at the subunit interfaces, the extracellular domain of the nicotinic acetylcholine receptor undergoes conformational changes, and agonist binding allosterically triggers opening of the ion channel. The soluble acetylcholine-binding protein (AChBP) from snail has been shown to be a structural and functional surrogate of the ligand-binding domain (LBD) of the receptor. Yet, individual AChBP species display disparate affinities for nicotinic ligands. The crystal structure of AChBP from Aplysia californica in the apo form reveals a more open loop C and distinctive positions for other surface loops, compared with previous structures. Analysis of Aplysia AChBP complexes with nicotinic ligands shows that loop C, which does not significantly change conformation upon binding of the antagonist, methyllycaconitine, further opens to accommodate the peptidic antagonist, alpha-conotoxin ImI, but wraps around the agonists lobeline and epibatidine. The structures also reveal extended and nonoverlapping interaction surfaces for the two antagonists, outside the binding loci for agonists. This comprehensive set of structures reflects a dynamic template for delineating further conformational changes of the LBD of the nicotinic receptor.
| | The line below this paragraph, {{ABSTRACT_PUBMED_16193063}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 16193063 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_16193063}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Conotoxin]] | | [[Category: Conotoxin]] |
| [[Category: Nicotinic acetylcholine receptor complex]] | | [[Category: Nicotinic acetylcholine receptor complex]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:58:59 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:03:19 2008'' |
