2bz5: Difference between revisions

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[[Image:2bz5.gif|left|200px]]
{{Seed}}
[[Image:2bz5.png|left|200px]]


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{{STRUCTURE_2bz5|  PDB=2bz5  |  SCENE=  }}  
{{STRUCTURE_2bz5|  PDB=2bz5  |  SCENE=  }}  


'''STRUCTURE-BASED DISCOVERY OF A NEW CLASS OF HSP90 INHIBITORS'''
===STRUCTURE-BASED DISCOVERY OF A NEW CLASS OF HSP90 INHIBITORS===




==Overview==
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Docking-based virtual screening identified 1-(2-phenol)-2-naphthol compounds as a new class of Hsp90 inhibitors of low to sub-micromolar potency. Here we report the binding affinities and cellular activities of several members of this class. A high resolution crystal structure of the most potent compound reveals its binding mode in the ATP binding site of Hsp90, providing a rationale for the observed activity of the series and suggesting strategies for developing compounds with improved properties.
The line below this paragraph, {{ABSTRACT_PUBMED_16202589}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16202589 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16202589}}


==About this Structure==
==About this Structure==
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[[Category: Nucleotide-binding]]
[[Category: Nucleotide-binding]]
[[Category: Phosphorylation]]
[[Category: Phosphorylation]]
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