2fic: Difference between revisions
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New page: left|200px<br /> <applet load="2fic" size="450" color="white" frame="true" align="right" spinBox="true" caption="2fic, resolution 1.99Å" /> '''The crystal structu... |
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[[Image:2fic.gif|left|200px]]<br /> | [[Image:2fic.gif|left|200px]]<br /><applet load="2fic" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="2fic" size=" | |||
caption="2fic, resolution 1.99Å" /> | caption="2fic, resolution 1.99Å" /> | ||
'''The crystal structure of the BAR domain from human Bin1/Amphiphysin II and its implications for molecular recognition'''<br /> | '''The crystal structure of the BAR domain from human Bin1/Amphiphysin II and its implications for molecular recognition'''<br /> | ||
==Overview== | ==Overview== | ||
BAR domains are found in proteins that bind and remodel membranes and | BAR domains are found in proteins that bind and remodel membranes and participate in cytoskeletal and nuclear processes. Here, we report the crystal structure of the BAR domain from the human Bin1 protein at 2.0 A resolution. Both the quaternary and tertiary architectures of the homodimeric Bin1BAR domain are built upon "knobs-into-holes" packing of side chains, like those found in conventional left-handed coiled-coils, and this packing governs the curvature of a putative membrane-engaging concave face. Our calculations indicate that the Bin1BAR domain contains two potential sites for protein-protein interactions on the convex face of the dimer. Comparative analysis of structural features reveals that at least three architectural subtypes of the BAR domain are encoded in the human genome, represented by the Arfaptin, Bin1/Amphiphysin, and IRSp53 BAR domains. We discuss how these principal groups may differ in their potential to form regulatory heterotypic interactions. | ||
==Disease== | |||
Known diseases associated with this structure: Myopathy, centronuclear, autosomal recessive OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601248 601248]] | |||
==About this Structure== | ==About this Structure== | ||
2FIC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with XE as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | 2FIC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=XE:'>XE</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FIC OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Casal, E.]] | [[Category: Casal, E.]] | ||
[[Category: Duhadaway, J | [[Category: Duhadaway, J B.]] | ||
[[Category: Federici, L.]] | [[Category: Federici, L.]] | ||
[[Category: Fernandez-Recio, J.]] | [[Category: Fernandez-Recio, J.]] | ||
[[Category: Laue, E | [[Category: Laue, E D.]] | ||
[[Category: Luisi, B | [[Category: Luisi, B F.]] | ||
[[Category: Miguel, R | [[Category: Miguel, R N.]] | ||
[[Category: Prendergast, G | [[Category: Prendergast, G C.]] | ||
[[Category: Priego, E | [[Category: Priego, E M.]] | ||
[[Category: Zhang, W.]] | [[Category: Zhang, W.]] | ||
[[Category: XE]] | [[Category: XE]] | ||
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[[Category: homodimer]] | [[Category: homodimer]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:21:39 2008'' | ||
