2c0n: Difference between revisions

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[[Image:2c0n.gif|left|200px]]
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{{STRUCTURE_2c0n|  PDB=2c0n  |  SCENE=  }}  
{{STRUCTURE_2c0n|  PDB=2c0n  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF A197 FROM STIV'''
===CRYSTAL STRUCTURE OF A197 FROM STIV===




==Overview==
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Sulfolobus turreted icosahedral virus (STIV) was the first icosahedral virus characterized from an archaeal host. It infects Sulfolobus species that thrive in the acidic hot springs (pH 2.9 to 3.9 and 72 to 92 degrees C) of Yellowstone National Park. The overall capsid architecture and the structure of its major capsid protein are very similar to those of the bacteriophage PRD1 and eukaryotic viruses Paramecium bursaria Chlorella virus 1 and adenovirus, suggesting a viral lineage that predates the three domains of life. The 17,663-base-pair, circular, double-stranded DNA genome contains 36 potential open reading frames, whose sequences generally show little similarity to other genes in the sequence databases. However, functional and evolutionary information may be suggested by a protein's three-dimensional structure. To this end, we have undertaken structural studies of the STIV proteome. Here we report our work on A197, the product of an STIV open reading frame. The structure of A197 reveals a GT-A fold that is common to many members of the glycosyltransferase superfamily. A197 possesses a canonical DXD motif and a putative catalytic base that are hallmarks of this family of enzymes, strongly suggesting a glycosyltransferase activity for A197. Potential roles for the putative glycosyltransferase activity of A197 and their evolutionary implications are discussed.
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{{ABSTRACT_PUBMED_16840342}}


==About this Structure==
==About this Structure==
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[[Category: Viral protein]]
[[Category: Viral protein]]
[[Category: Virus]]
[[Category: Virus]]
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Revision as of 03:24, 28 July 2008

File:2c0n.png

Template:STRUCTURE 2c0n

CRYSTAL STRUCTURE OF A197 FROM STIV

Template:ABSTRACT PUBMED 16840342

About this Structure

2C0N is a Single protein structure of sequence from Sulfolobus turreted icosahedral virus. Full crystallographic information is available from OCA.

Reference

Structure of A197 from Sulfolobus turreted icosahedral virus: a crenarchaeal viral glycosyltransferase exhibiting the GT-A fold., Larson ET, Reiter D, Young M, Lawrence CM, J Virol. 2006 Aug;80(15):7636-44. PMID:16840342

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