2c4g: Difference between revisions

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[[Image:2c4g.~~gif~~|left|200px]]

[[Image:2c4g.png|left|200px]]

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~~'''~~STRUCTURE OF CDK2-CYCLIN A WITH PHA-533514~~'''~~

===STRUCTURE OF CDK2-CYCLIN A WITH PHA-533514===

~~==Overview==~~

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~~We have recently reported about a new class of Aurora-A inhibitors based on a bicyclic tetrahydropyrrolo[3~~,~~4-c]pyrazole scaffold. Here we describe~~ the ~~synthesis and early expansion of CDK2/cyclin A-E inhibitors belonging~~ to the ~~same chemical class~~. ~~Synthesis of~~ the ~~compounds was accomplished using a solution~~-~~phase protocol amenable to rapid parallel expansion. Compounds with nanomolar activity in the biochemical assay and able to efficiently inhibit CDK2~~-~~mediated tumor cell proliferation have been obtained.~~

The line below this paragraph, {{ABSTRACT_PUBMED_16290148}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 16290148 is the PubMed ID number.

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==About this Structure==

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[[Category: Serine/threonine-protein kinase]]

[[Category: Transferase]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 21~~:14:08 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:57:32 2008''

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-[[Image:2c4g.gif|left|200px]]
+{{Seed}}
+[[Image:2c4g.png|left|200px]]
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 {{STRUCTURE_2c4g|  PDB=2c4g  |  SCENE=  }}
-'''STRUCTURE OF CDK2-CYCLIN A WITH PHA-533514'''
+===STRUCTURE OF CDK2-CYCLIN A WITH PHA-533514===
-==Overview==
+<!--
-We have recently reported about a new class of Aurora-A inhibitors based on a bicyclic tetrahydropyrrolo[3,4-c]pyrazole scaffold. Here we describe the synthesis and early expansion of CDK2/cyclin A-E inhibitors belonging to the same chemical class. Synthesis of the compounds was accomplished using a solution-phase protocol amenable to rapid parallel expansion. Compounds with nanomolar activity in the biochemical assay and able to efficiently inhibit CDK2-mediated tumor cell proliferation have been obtained.
+The line below this paragraph, {{ABSTRACT_PUBMED_16290148}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16290148 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16290148}}
 ==About this Structure==
@@ Line 48: / Line 52: @@
 [[Category: Serine/threonine-protein kinase]]
 [[Category: Transferase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 21:14:08 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:57:32 2008''