2c6b: Difference between revisions

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[[Image:2c6b.~~gif~~|left|200px]]

[[Image:2c6b.png|left|200px]]

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~~'''~~SOLUTION STRUCTURE OF THE C4 ZINC-FINGER DOMAIN OF HDM2~~'''~~

===SOLUTION STRUCTURE OF THE C4 ZINC-FINGER DOMAIN OF HDM2===

~~==Overview==~~

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~~HDM2 is a ubiquitin E3 ligase that is a key negative regulator of the tumor suppressor p53. Here~~, ~~we report~~ the ~~determination of~~ the ~~solution structure of the C4 zinc finger domain of HDM2 using multidimensional NMR~~. ~~The HDM2 C4 zinc finger domain has a fold consisting of a 3(10~~) ~~helix followed by four beta-strands~~, ~~which shares significant structural similarity to~~ the ~~zinc ribbon protein family. Family based sequence analysis identified two putative binding sites, one of which resembles an RNA binding motif~~.

The line below this paragraph, {{ABSTRACT_PUBMED_16385008}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 16385008 is the PubMed ID number.

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==About this Structure==

2C6B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C6B OCA].

2C6B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C6B OCA].

==Reference==

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[[Category: Zinc]]

[[Category: Zinc finger]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 21~~:19:23 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:07:59 2008''

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-[[Image:2c6b.gif|left|200px]]
+{{Seed}}
+[[Image:2c6b.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_2c6b|  PDB=2c6b  |  SCENE=  }}
-'''SOLUTION STRUCTURE OF THE C4 ZINC-FINGER DOMAIN OF HDM2'''
+===SOLUTION STRUCTURE OF THE C4 ZINC-FINGER DOMAIN OF HDM2===
-==Overview==
+<!--
-HDM2 is a ubiquitin E3 ligase that is a key negative regulator of the tumor suppressor p53. Here, we report the determination of the solution structure of the C4 zinc finger domain of HDM2 using multidimensional NMR. The HDM2 C4 zinc finger domain has a fold consisting of a 3(10) helix followed by four beta-strands, which shares significant structural similarity to the zinc ribbon protein family. Family based sequence analysis identified two putative binding sites, one of which resembles an RNA binding motif.
+The line below this paragraph, {{ABSTRACT_PUBMED_16385008}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16385008 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16385008}}
 ==About this Structure==
-C6B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C6B OCA].
+C6B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C6B OCA].
 ==Reference==
@@ Line 37: / Line 41: @@
 [[Category: Zinc]]
 [[Category: Zinc finger]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 21:19:23 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:07:59 2008''