2c6d: Difference between revisions

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[[Image:2c6d.gif|left|200px]]
{{Seed}}
[[Image:2c6d.png|left|200px]]


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{{STRUCTURE_2c6d|  PDB=2c6d  |  SCENE=  }}  
{{STRUCTURE_2c6d|  PDB=2c6d  |  SCENE=  }}  


'''AURORA A KINASE ACTIVATED MUTANT (T287D) IN COMPLEX WITH ADPNP'''
===AURORA A KINASE ACTIVATED MUTANT (T287D) IN COMPLEX WITH ADPNP===




==Overview==
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A novel series of 5-aminopyrimidinyl quinazolines has been developed from anilino-quinazoline 1, which was identified in a high throughput screen for Aurora A. Introduction of the pyrimidine ring and optimisation of the substituents both on this ring and at the C7 position of the quinazoline led to the discovery of compounds that are highly specific Aurora kinase inhibitors. Co-crystallisation of one of these inhibitors with a fragment of Aurora A shows the importance of the benzamido group in achieving selectivity.
The line below this paragraph, {{ABSTRACT_PUBMED_16337122}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16337122 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16337122}}


==About this Structure==
==About this Structure==
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[[Category: Serine/threonine-protein kinase]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Transferase]]
[[Category: Transferase]]
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