2c9l: Difference between revisions

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[[Image:2c9l.gif|left|200px]]
{{Seed}}
[[Image:2c9l.png|left|200px]]


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{{STRUCTURE_2c9l|  PDB=2c9l  |  SCENE=  }}  
{{STRUCTURE_2c9l|  PDB=2c9l  |  SCENE=  }}  


'''STRUCTURE OF THE EPSTEIN-BARR VIRUS ZEBRA PROTEIN'''
===STRUCTURE OF THE EPSTEIN-BARR VIRUS ZEBRA PROTEIN===




==Overview==
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Epstein-Barr virus (EBV) causes infectious mononucleosis and is linked to several human malignancies. EBV has a biphasic infection cycle consisting of a latent and a lytic, replicative phase. The switch from latent to lytic infection is triggered by the EBV immediate-early transcription factor ZEBRA (BZLF1, Zta, Z, EB1). We present the crystal structure of ZEBRA's DNA binding domain bound to an EBV lytic gene promoter element. ZEBRA exhibits a variant of the basic-region leucine zipper (bZIP) fold in which a C-terminal moiety stabilizes the coiled coil involved in dimer formation. The structure provides insights into ZEBRA's broad target site specificity, preferential activation of specific EBV promoters in their methylated state, ability to dimerize despite lacking a leucine zipper motif, and failure to heterodimerize with cellular bZIP proteins. The structure will allow for the design of new therapeutic agents that block activation of the EBV lytic cycle.
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{{ABSTRACT_PUBMED_16483937}}


==About this Structure==
==About this Structure==
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[[Category: Zebra]]
[[Category: Zebra]]
[[Category: Zta]]
[[Category: Zta]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 21:31:03 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:19:05 2008''

Revision as of 01:19, 29 July 2008

File:2c9l.png

Template:STRUCTURE 2c9l

STRUCTURE OF THE EPSTEIN-BARR VIRUS ZEBRA PROTEIN

Template:ABSTRACT PUBMED 16483937

About this Structure

2C9L is a Protein complex structure of sequences from Human herpesvirus 4. Full crystallographic information is available from OCA.

Reference

Structural basis of lytic cycle activation by the Epstein-Barr virus ZEBRA protein., Petosa C, Morand P, Baudin F, Moulin M, Artero JB, Muller CW, Mol Cell. 2006 Feb 17;21(4):565-72. PMID:16483937

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