2c9n: Difference between revisions

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[[Image:2c9n.~~gif~~|left|200px]]

[[Image:2c9n.png|left|200px]]

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~~'''~~STRUCTURE OF THE EPSTEIN-BARR VIRUS ZEBRA PROTEIN AT APPROXIMATELY 3.5 ANGSTROM RESOLUTION~~'''~~

===STRUCTURE OF THE EPSTEIN-BARR VIRUS ZEBRA PROTEIN AT APPROXIMATELY 3.5 ANGSTROM RESOLUTION===

~~==Overview==~~

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~~Epstein-Barr virus (EBV) causes infectious mononucleosis and is linked to several human malignancies. EBV has a biphasic infection cycle consisting of a latent and a lytic, replicative phase.~~ The ~~switch from latent to lytic infection is triggered by the EBV immediate-early transcription factor ZEBRA (BZLF1, Zta~~, Z, ~~EB1). We present~~ the ~~crystal structure of ZEBRA's DNA binding domain bound~~ to ~~an EBV lytic gene promoter element. ZEBRA exhibits a variant of~~ the ~~basic-region leucine zipper~~ (~~bZIP~~) ~~fold in which a C-terminal moiety stabilizes the coiled coil involved in dimer formation. The structure provides insights into ZEBRA's broad target site specificity~~, preferential activation of specific EBV promoters in their methylated state, ability to dimerize despite lacking a leucine zipper motif, and failure to heterodimerize with cellular bZIP proteins. The structure will allow for the ~~design of new therapeutic agents that block activation of the EBV lytic cycle~~.

The line below this paragraph, {{ABSTRACT_PUBMED_16483937}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 16483937 is the PubMed ID number.

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==About this Structure==

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[[Category: Zebra]]

[[Category: Zta]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 21~~:31:12 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:37:55 2008''

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-[[Image:2c9n.gif|left|200px]]
+{{Seed}}
+[[Image:2c9n.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_2c9n|  PDB=2c9n  |  SCENE=  }}
-'''STRUCTURE OF THE EPSTEIN-BARR VIRUS ZEBRA PROTEIN AT APPROXIMATELY 3.5 ANGSTROM RESOLUTION'''
+===STRUCTURE OF THE EPSTEIN-BARR VIRUS ZEBRA PROTEIN AT APPROXIMATELY 3.5 ANGSTROM RESOLUTION===
-==Overview==
+<!--
-Epstein-Barr virus (EBV) causes infectious mononucleosis and is linked to several human malignancies. EBV has a biphasic infection cycle consisting of a latent and a lytic, replicative phase. The switch from latent to lytic infection is triggered by the EBV immediate-early transcription factor ZEBRA (BZLF1, Zta, Z, EB1). We present the crystal structure of ZEBRA's DNA binding domain bound to an EBV lytic gene promoter element. ZEBRA exhibits a variant of the basic-region leucine zipper (bZIP) fold in which a C-terminal moiety stabilizes the coiled coil involved in dimer formation. The structure provides insights into ZEBRA's broad target site specificity, preferential activation of specific EBV promoters in their methylated state, ability to dimerize despite lacking a leucine zipper motif, and failure to heterodimerize with cellular bZIP proteins. The structure will allow for the design of new therapeutic agents that block activation of the EBV lytic cycle.
+The line below this paragraph, {{ABSTRACT_PUBMED_16483937}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16483937 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16483937}}
 ==About this Structure==
@@ Line 38: / Line 42: @@
 [[Category: Zebra]]
 [[Category: Zta]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 21:31:12 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:37:55 2008''