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| [[Image:2cjq.gif|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_2cjq| PDB=2cjq | SCENE= }} | | {{STRUCTURE_2cjq| PDB=2cjq | SCENE= }} |
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| '''BOVINE VIRAL DIARRHEA VIRUS CP7-R12 RNA-DEPENDENT RNA POLYMERASE'''
| | ===BOVINE VIRAL DIARRHEA VIRUS CP7-R12 RNA-DEPENDENT RNA POLYMERASE=== |
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| ==Overview==
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| Viral RNA-dependent RNA polymerases (RdRp) differ from DNA-dependent RNA polymerases, DNA-dependent DNA polymerases, and reverse transcriptases in that RdRps contain "fingertips" consisting of several polypeptide strands in the fingers domain interacting with the thumb domain. The crystal structure of bovine viral diarrhea virus (BVDV) RdRp containing an Asn438 duplication shows that the "N-terminal domain," which occurs only in pestiviruses such as BVDV, interacts with the polymerase component of the same polypeptide chain. This contrasts with the domain swapping observed in the previously determined structure of the BVDV NADL strain RdRp. By comparison with the NADL structure and through the use of biochemical data, it is possible that the N-terminal domain, in conjunction with the fingertips, is required to bind and assist the translocation of the RNA template. The partial disorder of the loop containing the additional Asn438 residue may explain the low replication rate of the recombinant compared with the wild-type virus.
| | The line below this paragraph, {{ABSTRACT_PUBMED_16843892}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 16843892 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_16843892}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Transmembrane]] | | [[Category: Transmembrane]] |
| [[Category: Viral polymerase]] | | [[Category: Viral polymerase]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 22:18:35 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:45:24 2008'' |
