2ct9: Difference between revisions

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[[Image:2ct9.gif|left|200px]]
{{Seed}}
[[Image:2ct9.png|left|200px]]


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{{STRUCTURE_2ct9|  PDB=2ct9  |  SCENE=  }}  
{{STRUCTURE_2ct9|  PDB=2ct9  |  SCENE=  }}  


'''The crystal structure of calcineurin B homologous proein 1 (CHP1)'''
===The crystal structure of calcineurin B homologous proein 1 (CHP1)===




==Overview==
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Calcineurin B homologous protein 1 (CHP1), also known as p22, is a calcium-binding EF-hand protein that plays a role in membrane trafficking. It binds to multiple effector proteins, including Na(+)/H(+) exchangers, a serine/threonine kinase, and calcineurin, potentially modulating their function. The crystal structure of calcium-bound CHP1 from rat has been determined at 2.2 Angstroms of resolution. The molecule has a compact alpha-helical structure containing four EF-hands. The overall folding topology of the protein is similar to that of the regulatory B subunit of calcineurin and to that of calcium- and integrin-binding protein. The calcium ion is coordinated in typical fashion in the third and fourth EF-hands, but the first and second EF-hands contain no calcium ion. The first EF-hand is maintained by internal interactions, and the second EF-hand is stabilized by hydrophobic interactions. CHP1 contains a hydrophobic pocket on the opposite side of the protein to the EF-hands that has been implicated in ligand binding.
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{{ABSTRACT_PUBMED_15987692}}


==About this Structure==
==About this Structure==
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[[Category: Calcium binding protein]]
[[Category: Calcium binding protein]]
[[Category: Ef-hand]]
[[Category: Ef-hand]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:00:21 2008''

Revision as of 06:00, 28 July 2008

File:2ct9.png

Template:STRUCTURE 2ct9

The crystal structure of calcineurin B homologous proein 1 (CHP1)

Template:ABSTRACT PUBMED 15987692

About this Structure

2CT9 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structural characterization of calcineurin B homologous protein 1., Naoe Y, Arita K, Hashimoto H, Kanazawa H, Sato M, Shimizu T, J Biol Chem. 2005 Sep 16;280(37):32372-8. Epub 2005 Jun 29. PMID:15987692

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