2cyf: Difference between revisions

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[[Image:2cyf.gif|left|200px]]
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[[Image:2cyf.png|left|200px]]


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{{STRUCTURE_2cyf|  PDB=2cyf  |  SCENE=  }}  
{{STRUCTURE_2cyf|  PDB=2cyf  |  SCENE=  }}  


'''The Crystal Structure of Canavalia Maritima Lectin (ConM) in Complex with Trehalose and Maltose'''
===The Crystal Structure of Canavalia Maritima Lectin (ConM) in Complex with Trehalose and Maltose===




==Overview==
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The crystal structure of Canavalia maritima lectin (ConM) complexed with trehalose and maltose revealed relevant point mutations in ConA-like lectins. ConM with the disaccharides and other ConA-like lectins complexed with carbohydrates demonstrated significant differences in the position of H-bonds. The main difference in the ConM structure is the replacement of Pro202 by Ser202, a residue that promotes the approximation of Tyr12 to the carbohydrate-binding site. The O-6' of the second glucose ring in maltose interacts with Tyr12, while in trehalose the interaction is established by the O-2' and Tyr12, explaining the higher affinity of ConM for disaccharides compared to monosaccharides.
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{{ABSTRACT_PUBMED_16677825}}


==About this Structure==
==About this Structure==
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[[Category: Lectin]]
[[Category: Lectin]]
[[Category: Maltose]]
[[Category: Maltose]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 23:21:14 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:41:38 2008''

Revision as of 12:41, 27 July 2008

File:2cyf.png

Template:STRUCTURE 2cyf

The Crystal Structure of Canavalia Maritima Lectin (ConM) in Complex with Trehalose and Maltose

Template:ABSTRACT PUBMED 16677825

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structure of a lectin from Canavalia maritima (ConM) in complex with trehalose and maltose reveals relevant mutation in ConA-like lectins., Delatorre P, Rocha BA, Gadelha CA, Santi-Gadelha T, Cajazeiras JB, Souza EP, Nascimento KS, Freire VN, Sampaio AH, Azevedo WF Jr, Cavada BS, J Struct Biol. 2006 Jun;154(3):280-6. Epub 2006 Apr 21. PMID:16677825

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