2giu: Difference between revisions
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New page: left|200px<br /> <applet load="2giu" size="450" color="white" frame="true" align="right" spinBox="true" caption="2giu, resolution 2.2Å" /> '''Human estrogen recep... |
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[[Image:2giu.gif|left|200px]]<br /> | [[Image:2giu.gif|left|200px]]<br /><applet load="2giu" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="2giu" size=" | |||
caption="2giu, resolution 2.2Å" /> | caption="2giu, resolution 2.2Å" /> | ||
'''Human estrogen receptor beta ligand-binding domain in complex with compound 45'''<br /> | '''Human estrogen receptor beta ligand-binding domain in complex with compound 45'''<br /> | ||
==Overview== | ==Overview== | ||
Synthesis and derivatization of a series of substituted | Synthesis and derivatization of a series of substituted tetrahydrofluorenone analogs giving potent, ERbeta subtype selective ligands are described. Several analogs possessing ERbeta binding affinities comparable to 17beta-estradiol but with greater than 75-fold selectivity over ERalpha are reported. | ||
==About this Structure== | ==About this Structure== | ||
2GIU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with FBR as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | 2GIU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=FBR:'>FBR</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIU OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Fitzgerald, P | [[Category: Fitzgerald, P M.D.]] | ||
[[Category: Sharma, N.]] | [[Category: Sharma, N.]] | ||
[[Category: FBR]] | [[Category: FBR]] | ||
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[[Category: transcription factor]] | [[Category: transcription factor]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:32:05 2008'' | ||
