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| {{STRUCTURE_2d3v| PDB=2d3v | SCENE= }} | | {{STRUCTURE_2d3v| PDB=2d3v | SCENE= }} |
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| '''Crystal Structure of Leukocyte Ig-like Receptor A5 (LILRA5/LIR9/ILT11)'''
| | ===Crystal Structure of Leukocyte Ig-like Receptor A5 (LILRA5/LIR9/ILT11)=== |
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| ==Overview==
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| Human leukocyte Ig-like receptor B1 (LILRB1) and B2 (LILRB2) belong to "Group 1" receptors and recognize a broad range of major histocompatibility complex class I molecules (MHCIs). In contrast, "Group 2" receptors show low similarity with LILRB1/B2, and their ligands remain to be identified. To date, the structural and functional characteristics of Group 2 LILRs are poorly understood. Here we report the crystal structure of the extracellular domain of LILRA5, which is an activating Group 2 LILR expressed on monocytes and neutrophils. Unexpectedly, the structure showed large changes in structural conformation and charge distribution in the region corresponding to the MHCI binding site of LILRB1/B2, which are also distinct from killer cell Ig-like receptors and Fc alpha receptors. These changes probably confer the structural hindrance for the MHCI binding, and their key amino acid substitutions are well conserved in Group 2 LILRs. Consistently, the surface plasmon resonance and flow cytometric analyses demonstrated that LILRA5 exhibited no affinities to all tested MHCIs. These results raised the possibility that LILRA5 as well as Group 2 LILRs do not play a role in any MHCI recognition but could possibly bind to non-MHCI ligand(s) on the target cells to provide a novel immune regulation mechanism.
| | The line below this paragraph, {{ABSTRACT_PUBMED_16675463}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 16675463 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_16675463}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Shiroishi, M.]] | | [[Category: Shiroishi, M.]] |
| [[Category: Immunoglobulin-like fold]] | | [[Category: Immunoglobulin-like fold]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 23:39:25 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:15:58 2008'' |
