2d4r: Difference between revisions

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[[Image:2d4r.gif|left|200px]]
{{Seed}}
[[Image:2d4r.png|left|200px]]


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{{STRUCTURE_2d4r|  PDB=2d4r  |  SCENE=  }}  
{{STRUCTURE_2d4r|  PDB=2d4r  |  SCENE=  }}  


'''Crystal structure of TTHA0849 from Thermus thermophilus HB8'''
===Crystal structure of TTHA0849 from Thermus thermophilus HB8===




==Overview==
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The crystal structure of a conserved hypothetical protein, TTHA0849 from Thermus thermophilus HB8, has been determined at 2.4 A resolution as a part of a structural and functional genomics project on T. thermophilus HB8. The main-chain folding shows a compact alpha+beta motif, forming a hydrophobic cavity in the molecule. A structural similarity search reveals that it resembles those steroidogenic acute regulatory proteins that contain the lipid-transfer (START) domain, even though TTHA0849 shows comparatively weak sequence identity to polyketide cyclases. However, the size of the ligand-binding cavity is distinctly smaller than other START domain-containing proteins, suggesting that it catalyses the transfer of smaller ligand molecules.
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{{ABSTRACT_PUBMED_16511226}}


==About this Structure==
==About this Structure==
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[[Category: Start domain]]
[[Category: Start domain]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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