2d52: Difference between revisions

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[[Image:2d52.gif|left|200px]]
{{Seed}}
[[Image:2d52.png|left|200px]]


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{{STRUCTURE_2d52|  PDB=2d52  |  SCENE=  }}  
{{STRUCTURE_2d52|  PDB=2d52  |  SCENE=  }}  


'''Pentaketide chromone synthase (M207G mutant complexed with Coa)'''
===Pentaketide chromone synthase (M207G mutant complexed with Coa)===




==Overview==
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The crystal structures of a wild-type and a mutant PCS, a novel plant type III polyketide synthase from a medicinal plant, Aloe arborescens, were solved at 1.6 A resolution. The crystal structures revealed that the pentaketide-producing wild-type and the octaketide-producing M207G mutant shared almost the same overall folding, and that the large-to-small substitution dramatically increases the volume of the polyketide-elongation tunnel by opening a gate to two hidden pockets behind the active site of the enzyme. The chemically inert active site residue 207 thus controls the number of condensations of malonyl-CoA, solely depending on the steric bulk of the side chain. These findings not only provided insight into the polyketide formation reaction, but they also suggested strategies for the engineered biosynthesis of polyketides.
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{{ABSTRACT_PUBMED_17462571}}


==About this Structure==
==About this Structure==
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[[Category: Pentaketide chromone synthase]]
[[Category: Pentaketide chromone synthase]]
[[Category: Polyketide synthase]]
[[Category: Polyketide synthase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 23:43:13 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:36:00 2008''

Revision as of 18:36, 28 July 2008

File:2d52.png

Template:STRUCTURE 2d52

Pentaketide chromone synthase (M207G mutant complexed with Coa)

Template:ABSTRACT PUBMED 17462571

About this Structure

2D52 is a Single protein structure of sequence from Aloe arborescens. Full crystallographic information is available from OCA.

Reference

Structural insight into chain-length control and product specificity of pentaketide chromone synthase from Aloe arborescens., Morita H, Kondo S, Oguro S, Noguchi H, Sugio S, Abe I, Kohno T, Chem Biol. 2007 Apr;14(4):359-69. PMID:17462571

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