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| [[Image:2dez.jpg|left|200px]] | | {{Seed}} |
| | [[Image:2dez.png|left|200px]] |
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| {{STRUCTURE_2dez| PDB=2dez | SCENE= }} | | {{STRUCTURE_2dez| PDB=2dez | SCENE= }} |
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| '''Structure of human PYY'''
| | ===Structure of human PYY=== |
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| ==Overview==
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| PYY3-36 is a biopharmaceutical antiobesity agent under development as well as an endogenous satiety hormone, which is generated by dipeptidyl peptidase-IV digestion of polypetide YY (PYY), and in contrast to the parent hormone, PYY is highly selective for the Y2 versus the Y1 receptor. NMR analysis revealed a highly ordered, back-folded structure for human PYY in aqueous solution similar to the classical PP-fold structure of pancreatic polypeptide. The NMR analysis of PYY3-36 also showed a folded structure resembling a PP-fold, which however was characterized by far fewer long distance NOEs than the PP-fold observed in the full-length peptide. This suggests that either a conformational change has occurred in the N-terminal segment of PYY3-36 or that this segments is characterized by larger dynamics. The study supports the notion that the PP-fold is crucial for establishing simultaneous interactions with two subsites in the receptor for binding of, respectively, the N- and C-terminal ends of PYY. The Y2 receptor only requires recognition of the C-terminal segment of the molecule as displayed by the Y2 selective PYY3-36.
| | The line below this paragraph, {{ABSTRACT_PUBMED_16819834}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 16819834 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_16819834}} |
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| ==About this Structure== | | ==About this Structure== |
| 2DEZ is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DEZ OCA]. | | 2DEZ is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DEZ OCA]. |
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| ==Reference== | | ==Reference== |
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| [[Category: Peptide]] | | [[Category: Peptide]] |
| [[Category: Pp-fold]] | | [[Category: Pp-fold]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 00:17:59 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:16:16 2008'' |
