2dx5: Difference between revisions

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[[Image:2dx5.gif|left|200px]]
{{Seed}}
[[Image:2dx5.png|left|200px]]


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{{STRUCTURE_2dx5|  PDB=2dx5  |  SCENE=  }}  
{{STRUCTURE_2dx5|  PDB=2dx5  |  SCENE=  }}  


'''The complex structure between the mouse EAP45-GLUE domain and ubiquitin'''
===The complex structure between the mouse EAP45-GLUE domain and ubiquitin===




==Overview==
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ESCRT-II, a complex that sorts ubiquitinated membrane proteins to lysosomes, localizes to endosomes through interaction between the Vps36 subunit's GLUE domain and phosphatidylinositides (PIs). In yeast, a ubiquitin (Ub)-interacting NZF domain is inserted in Vps36 GLUE, whereas its mammalian counterpart, Eap45 GLUE, lacks the NZF domain. In the Eap45 GLUE-Ub complex structure, Ub binds far from the proposed PI-binding site of Eap45 GLUE, suggesting their independent binding.
The line below this paragraph, {{ABSTRACT_PUBMED_17057714}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17057714 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17057714}}


==About this Structure==
==About this Structure==
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[[Category: Protein-protein complex]]
[[Category: Protein-protein complex]]
[[Category: Ubiquitin]]
[[Category: Ubiquitin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 01:33:21 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:08:21 2008''
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