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| [[Image:2dyp.gif|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_2dyp| PDB=2dyp | SCENE= }} | | {{STRUCTURE_2dyp| PDB=2dyp | SCENE= }} |
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| '''Crystal Structure of LILRB2(LIR2/ILT4/CD85d) complexed with HLA-G'''
| | ===Crystal Structure of LILRB2(LIR2/ILT4/CD85d) complexed with HLA-G=== |
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| ==Overview==
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| HLA-G is a nonclassical MHC class I (MHCI) molecule that can suppress a wide range of immune responses in the maternal-fetal interface. The human inhibitory immune receptors leukocyte Ig-like receptor (LILR) B1 [also called LIR1, Ig-like transcript 2 (ILT2), or CD85j] and LILRB2 (LIR2/ILT4/CD85d) preferentially recognize HLA-G. HLA-G inherently exhibits various forms, including beta(2)-microglobulin (beta(2)m)-free and disulfide-linked dimer forms. Notably, LILRB1 cannot recognize the beta(2)m-free form of HLA-G or HLA-B27, but LILRB2 can recognize the beta(2)m-free form of HLA-B27. To date, the structural basis for HLA-G/LILR recognition remains to be examined. Here, we report the 2.5-A resolution crystal structure of the LILRB2/HLA-G complex. LILRB2 exhibits an overlapping but distinct MHCI recognition mode compared with LILRB1 and dominantly recognizes the hydrophobic site of the HLA-G alpha3 domain. NMR binding studies also confirmed these LILR recognition differences on both conformed (heavy chain/peptide/beta(2)m) and free forms of beta(2)m. Binding studies using beta(2)m-free MHCIs revealed differential beta(2)m-dependent LILR-binding specificities. These results suggest that subtle structural differences between LILRB family members cause the distinct binding specificities to various forms of HLA-G and other MHCIs, which may in turn regulate immune suppression.
| | The line below this paragraph, {{ABSTRACT_PUBMED_17056715}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 17056715 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_17056715}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Shiroishi, M.]] | | [[Category: Shiroishi, M.]] |
| [[Category: Immunoglobulin-like]] | | [[Category: Immunoglobulin-like]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 01:37:53 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:17:31 2008'' |
