2dz7: Difference between revisions

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[[Image:2dz7.jpg|left|200px]]
{{Seed}}
[[Image:2dz7.png|left|200px]]


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{{STRUCTURE_2dz7|  PDB=2dz7  |  SCENE=  }}  
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'''DNA Octaplex Formation with an I-Motif of A-Quartets: The Revised Crystal Structure of d(GCGAAAGC)'''
===DNA Octaplex Formation with an I-Motif of A-Quartets: The Revised Crystal Structure of d(GCGAAAGC)===




==Overview==
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The crystal structure of the tetragonal form of d(gcGAAAgc) has been revised and reasonably refined including the disordered residues. The two DNA strands form a base-intercalated duplex, and the four duplexes are assembled according to the crystallographic 222 symmetry to form an octaplex. In the central region, the eight strands are associated by I-motif of double A-quartets. Furthermore, eight hydrated-magnesium cations link the four duplexes to support the octaplex formation. Based on these structural features, a proposal that folding of d(GAAA)n, found in the non-coding region of genomes, into an octaplex can induce slippage during replication to facilitate length polymorphism is presented.
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{{ABSTRACT_PUBMED_17062599}}


==About this Structure==
==About this Structure==
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[[Category: Non-coding dna]]
[[Category: Non-coding dna]]
[[Category: Vntr]]
[[Category: Vntr]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 01:38:47 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:52:29 2008''

Revision as of 11:52, 29 July 2008

File:2dz7.png

Template:STRUCTURE 2dz7

DNA Octaplex Formation with an I-Motif of A-Quartets: The Revised Crystal Structure of d(GCGAAAGC)

Template:ABSTRACT PUBMED 17062599

About this Structure

Full crystallographic information is available from OCA.

Reference

DNA octaplex formation with an I-motif of water-mediated A-quartets: reinterpretation of the crystal structure of d(GCGAAAGC)., Sato Y, Mitomi K, Sunami T, Kondo J, Takenaka A, J Biochem. 2006 Dec;140(6):759-62. Epub 2006 Oct 24. PMID:17062599

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