2e2b: Difference between revisions

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[[Image:2e2b.jpg|left|200px]]
{{Seed}}
[[Image:2e2b.png|left|200px]]


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{{STRUCTURE_2e2b|  PDB=2e2b  |  SCENE=  }}  
{{STRUCTURE_2e2b|  PDB=2e2b  |  SCENE=  }}  


'''Crystal structure of the c-Abl kinase domain in complex with INNO-406'''
===Crystal structure of the c-Abl kinase domain in complex with INNO-406===




==Overview==
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To investigate why 3-substituted benzamide derivatives show dual inhibition of Abl and Lyn protein tyrosine kinases, we determined their inhibitory activities against Abl and Lyn, carried out molecular modeling, and conducted a structure-activity relationship study with the aid of a newly determined X-ray structure of the Abl/Lyn dual inhibitor INNO-406 (formerly known as NS-187) bound to human Abl. We found that this series of compounds interacted with both kinases in very similar ways, so that they can inhibit both kinases effectively.
The line below this paragraph, {{ABSTRACT_PUBMED_17376680}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_17376680}}


==About this Structure==
==About this Structure==
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[[Category: Inno-406]]
[[Category: Inno-406]]
[[Category: Kinase]]
[[Category: Kinase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 01:47:30 2008''
 
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