2hiu: Difference between revisions
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New page: left|200px<br /> <applet load="2hiu" size="450" color="white" frame="true" align="right" spinBox="true" caption="2hiu" /> '''NMR STRUCTURE OF HUMAN INSULIN IN 20% ACETI... |
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[[Image:2hiu.gif|left|200px]]<br /> | [[Image:2hiu.gif|left|200px]]<br /><applet load="2hiu" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="2hiu" size=" | |||
caption="2hiu" /> | caption="2hiu" /> | ||
'''NMR STRUCTURE OF HUMAN INSULIN IN 20% ACETIC ACID, ZINC-FREE, 10 STRUCTURES'''<br /> | '''NMR STRUCTURE OF HUMAN INSULIN IN 20% ACETIC ACID, ZINC-FREE, 10 STRUCTURES'''<br /> | ||
==Overview== | ==Overview== | ||
We have determined the structure of a metastable disulphide isomer of | We have determined the structure of a metastable disulphide isomer of human insulin. Although not observed for proinsulin folding or insulin-chain recombination, the isomer retains ordered secondary structure and a compact hydrophobic core. Comparison with native insulin reveals a global rearrangement in the orientation of A- and B-chains. One face of the protein's surface is nevertheless in common between native and non-native structures. This face contains receptor-binding determinants, rationalizing the partial biological activity of the isomer. Structures of native and non-native disulphide isomers also define alternative three-dimensional templates. Threading of insulin-like sequences provide an experimental realization of the inverse protein-folding problem. | ||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
2HIU is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure | 2HIU is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry 1HIU. The following page contains interesting information on the relation of 2HIU with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb14_1.html Insulin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HIU OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Insulin]] | [[Category: Insulin]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Chance, R | [[Category: Chance, R E.]] | ||
[[Category: Frank, B | [[Category: Frank, B H.]] | ||
[[Category: Gozani, S | [[Category: Gozani, S N.]] | ||
[[Category: Hoffmann, J | [[Category: Hoffmann, J A.]] | ||
[[Category: Hua, Q | [[Category: Hua, Q X.]] | ||
[[Category: Weiss, M | [[Category: Weiss, M A.]] | ||
[[Category: glucose metabolism]] | [[Category: glucose metabolism]] | ||
[[Category: hormone]] | [[Category: hormone]] | ||
[[Category: insulin]] | [[Category: insulin]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:42:21 2008'' | ||
