2hm1: Difference between revisions
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New page: left|200px<br /> <applet load="2hm1" size="450" color="white" frame="true" align="right" spinBox="true" caption="2hm1, resolution 2.200Å" /> '''Crystal Structure ... |
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[[Image:2hm1.gif|left|200px]]<br /> | [[Image:2hm1.gif|left|200px]]<br /><applet load="2hm1" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="2hm1" size=" | |||
caption="2hm1, resolution 2.200Å" /> | caption="2hm1, resolution 2.200Å" /> | ||
'''Crystal Structure of human beta-secretase (BACE) in the presence of an inhibitor (2)'''<br /> | '''Crystal Structure of human beta-secretase (BACE) in the presence of an inhibitor (2)'''<br /> | ||
==Overview== | ==Overview== | ||
We describe an optimized series of acyclic hydroxyethylamine transition | We describe an optimized series of acyclic hydroxyethylamine transition state isosteres of beta-secretase that incorporates a variety of P(2) side chains that yield potent inhibitors with excellent cellular activity. A 2.2A crystal structure of compound 13 is shown. | ||
==About this Structure== | ==About this Structure== | ||
2HM1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with LIQ as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] Full crystallographic information is available from [http:// | 2HM1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=LIQ:'>LIQ</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HM1 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Memapsin 2]] | [[Category: Memapsin 2]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Benson, T | [[Category: Benson, T E.]] | ||
[[Category: Emmons, T | [[Category: Emmons, T L.]] | ||
[[Category: Paddock, D | [[Category: Paddock, D J.]] | ||
[[Category: Prince, D | [[Category: Prince, D B.]] | ||
[[Category: Tomasselli, A | [[Category: Tomasselli, A G.]] | ||
[[Category: LIQ]] | [[Category: LIQ]] | ||
[[Category: protein-inhibitor complex]] | [[Category: protein-inhibitor complex]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:43:19 2008'' | ||
