2hn7: Difference between revisions
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New page: left|200px<br /> <applet load="2hn7" size="450" color="white" frame="true" align="right" spinBox="true" caption="2hn7, resolution 1.60Å" /> '''HLA-A*1101 in compl... |
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[[Image:2hn7.gif|left|200px]]<br /> | [[Image:2hn7.gif|left|200px]]<br /><applet load="2hn7" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="2hn7" size=" | |||
caption="2hn7, resolution 1.60Å" /> | caption="2hn7, resolution 1.60Å" /> | ||
'''HLA-A*1101 in complex with HBV peptide homologue'''<br /> | '''HLA-A*1101 in complex with HBV peptide homologue'''<br /> | ||
==Overview== | ==Overview== | ||
A high-resolution structure of the human MHC-I molecule HLA-A*1101 is | A high-resolution structure of the human MHC-I molecule HLA-A*1101 is presented in which it forms a complex with a sequence homologue of a peptide that occurs naturally in hepatitis B virus DNA polymerase. The sequence of the bound peptide is AIMPARFYPK, while that of the corresponding natural peptide is LIMPARFYPK. The peptide does not make efficient use of the middle E pocket for binding, which leads to a rather superficial and exposed binding mode for the central peptide residues. Despite this, the peptide binds with high affinity (IC50 of 31 nM). | ||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
2HN7 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | 2HN7 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HN7 OCA]. | ||
==Reference== | ==Reference== | ||
Structure of HLA-A*1101 in complex with a hepatitis B peptide homologue., Blicher T, Kastrup JS, Pedersen LO, Buus S, Gajhede M, Acta | Structure of HLA-A*1101 in complex with a hepatitis B peptide homologue., Blicher T, Kastrup JS, Pedersen LO, Buus S, Gajhede M, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Dec 1;62(Pt, 12):1179-84. Epub 2006 Nov 4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17142892 17142892] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: peptide-mhc-complex]] | [[Category: peptide-mhc-complex]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:43:37 2008'' | ||
