2i0g: Difference between revisions

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[[Image:2i0g.gif|left|200px]]<br />

[[Image:2i0g.gif|left|200px]]<br /><applet load="2i0g" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="2i0g" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="2i0g, resolution 2.500Å" />

'''Benzopyrans are Selective Estrogen Receptor beta Agonists (SERBAs) with Novel Activity in Models of Benign Prostatic Hyperplasia'''<br />

==Overview==

Benzopyran selective estrogen receptor beta agonist-1 (SERBA-1) shows, potent, selective binding and agonist function in estrogen receptor beta, (ERbeta) in vitro assays. X-ray crystal structures of SERBA-1 in ERalpha, and beta help explain observed beta-selectivity of this ligand. SERBA-1 in, vivo demonstrates involution of the ventral prostate in CD-1 mice (ERbeta, effect), while having no effect on gonadal hormone levels (ERalpha effect), at 10x the efficacious dose, consistent with in vitro properties of this, molecule.

Benzopyran selective estrogen receptor beta agonist-1 (SERBA-1) shows potent, selective binding and agonist function in estrogen receptor beta (ERbeta) in vitro assays. X-ray crystal structures of SERBA-1 in ERalpha and beta help explain observed beta-selectivity of this ligand. SERBA-1 in vivo demonstrates involution of the ventral prostate in CD-1 mice (ERbeta effect), while having no effect on gonadal hormone levels (ERalpha effect) at 10x the efficacious dose, consistent with in vitro properties of this molecule.

==About this Structure==

2I0G is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with I0G as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=2I0G OCA].

2I0G is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=I0G:'>I0G</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I0G OCA].

==Reference==

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[[Category: nuclear receptor]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov 12 22~~:39:~~18 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:47:43 2008''

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@@ Line 1: / Line 1: @@
-[[Image:2i0g.gif|left|200px]]<br />
+[[Image:2i0g.gif|left|200px]]<br /><applet load="2i0g" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="2i0g" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="2i0g, resolution 2.500&Aring;" />
 '''Benzopyrans are Selective Estrogen Receptor beta Agonists (SERBAs) with Novel Activity in Models of Benign Prostatic Hyperplasia'''<br />
 ==Overview==
-Benzopyran selective estrogen receptor beta agonist-1 (SERBA-1) shows, potent, selective binding and agonist function in estrogen receptor beta, (ERbeta) in vitro assays. X-ray crystal structures of SERBA-1 in ERalpha, and beta help explain observed beta-selectivity of this ligand. SERBA-1 in, vivo demonstrates involution of the ventral prostate in CD-1 mice (ERbeta, effect), while having no effect on gonadal hormone levels (ERalpha effect), at 10x the efficacious dose, consistent with in vitro properties of this, molecule.
+Benzopyran selective estrogen receptor beta agonist-1 (SERBA-1) shows potent, selective binding and agonist function in estrogen receptor beta (ERbeta) in vitro assays. X-ray crystal structures of SERBA-1 in ERalpha and beta help explain observed beta-selectivity of this ligand. SERBA-1 in vivo demonstrates involution of the ventral prostate in CD-1 mice (ERbeta effect), while having no effect on gonadal hormone levels (ERalpha effect) at 10x the efficacious dose, consistent with in vitro properties of this molecule.
 ==About this Structure==
-I0G is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with I0G as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2I0G OCA].
+I0G is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=I0G:'>I0G</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I0G OCA].
 ==Reference==
@@ Line 19: / Line 18: @@
 [[Category: nuclear receptor]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 22:39:18 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:47:43 2008''