2i0j: Difference between revisions
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New page: left|200px<br /> <applet load="2i0j" size="450" color="white" frame="true" align="right" spinBox="true" caption="2i0j, resolution 2.900Å" /> '''Benzopyrans are Se... |
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[[Image:2i0j.gif|left|200px]]<br /> | [[Image:2i0j.gif|left|200px]]<br /><applet load="2i0j" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="2i0j" size=" | |||
caption="2i0j, resolution 2.900Å" /> | caption="2i0j, resolution 2.900Å" /> | ||
'''Benzopyrans are Selective Estrogen Receptor beta Agonists (SERBAs) with Novel Activity in Models of Benign Prostatic Hyperplasia'''<br /> | '''Benzopyrans are Selective Estrogen Receptor beta Agonists (SERBAs) with Novel Activity in Models of Benign Prostatic Hyperplasia'''<br /> | ||
==Overview== | ==Overview== | ||
Benzopyran selective estrogen receptor beta agonist-1 (SERBA-1) shows | Benzopyran selective estrogen receptor beta agonist-1 (SERBA-1) shows potent, selective binding and agonist function in estrogen receptor beta (ERbeta) in vitro assays. X-ray crystal structures of SERBA-1 in ERalpha and beta help explain observed beta-selectivity of this ligand. SERBA-1 in vivo demonstrates involution of the ventral prostate in CD-1 mice (ERbeta effect), while having no effect on gonadal hormone levels (ERalpha effect) at 10x the efficacious dose, consistent with in vitro properties of this molecule. | ||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
2I0J is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with I0G as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | 2I0J is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=I0G:'>I0G</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I0J OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: nuclear receptor ligand binding domain]] | [[Category: nuclear receptor ligand binding domain]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:47:45 2008'' | ||
