2erm: Difference between revisions

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[[Image:2erm.jpg|left|200px]]
{{Seed}}
[[Image:2erm.png|left|200px]]


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{{STRUCTURE_2erm|  PDB=2erm  |  SCENE=  }}  
{{STRUCTURE_2erm|  PDB=2erm  |  SCENE=  }}  


'''Solution structure of a biologically active human FGF-1 monomer, complexed to a hexasaccharide heparin-analogue'''
===Solution structure of a biologically active human FGF-1 monomer, complexed to a hexasaccharide heparin-analogue===




==Overview==
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The 3D structure of a complex formed by the acidic fibroblast growth factor (FGF-1) and a specifically designed synthetic heparin hexasaccharide has been determined by NMR spectroscopy. This hexasaccharide can substitute natural heparins in FGF-1 mitogenesis assays, in spite of not inducing any apparent dimerization of the growth factor. The use of this well defined synthetic heparin analogue has allowed us to perform a detailed NMR structural analysis of the heparin-FGF interaction, overcoming the limitations of NMR to deal with the high molecular mass and heterogeneity of the FGF-1 oligomers formed in the presence of natural heparin fragments. Our results confirm that glycosaminoglycans induced FGF-1 dimerization either in a cis or trans disposition with respect to the heparin chain is not an absolute requirement for biological activity.
The line below this paragraph, {{ABSTRACT_PUBMED_16995857}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16995857 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16995857}}


==About this Structure==
==About this Structure==
2ERM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERM OCA].  
2ERM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERM OCA].  


==Reference==
==Reference==
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[[Category: Heparin-like hexasaccharide]]
[[Category: Heparin-like hexasaccharide]]
[[Category: Protein-carbohydrate complex]]
[[Category: Protein-carbohydrate complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 03:02:19 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:39:00 2008''
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