2es5: Difference between revisions

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[[Image:2es5.~~gif~~|left|200px]]

[[Image:2es5.png|left|200px]]

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~~'''~~Structure of the SRE RNA~~'''~~

===Structure of the SRE RNA===

~~==Overview==~~

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~~Although the abundant sterile alpha motif (SAM) domain was originally classified as a protein-protein interaction domain~~, ~~it has recently been shown that certain SAM domains have~~ the ~~ability~~ to ~~bind RNA, defining a new type of post-transcriptional gene regulator. To further understand~~ the ~~function of SAM-RNA recognition, we determined the solution structures of the SAM domain of the Saccharomyces cerevisiae Vts1p~~ (~~Vts1p-SAM) and the Smaug response element (SRE) stem-loop RNA~~ as ~~a complex and in isolation~~. ~~The structures show that Vts1p-SAM recognizes predominantly the shape of the SRE rather than its sequence, with the exception of a G located at the tip of the pentaloop~~. ~~Using microarray gene profiling~~, ~~we identified several genes in S. cerevisiae that seem to be regulated by Vts1p and contain one or more copies of~~ the ~~SRE~~.

The line below this paragraph, {{ABSTRACT_PUBMED_16429156}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 16429156 is the PubMed ID number.

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==About this Structure==

Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ES5 OCA].

Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ES5 OCA].

==Reference==

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[[Category: Rna structure]]

[[Category: Stem-loop]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 03~~:03:19 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:51:52 2008''

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-[[Image:2es5.gif|left|200px]]
+{{Seed}}
+[[Image:2es5.png|left|200px]]
 <!--
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 {{STRUCTURE_2es5|  PDB=2es5  |  SCENE=  }}
-'''Structure of the SRE RNA'''
+===Structure of the SRE RNA===
-==Overview==
+<!--
-Although the abundant sterile alpha motif (SAM) domain was originally classified as a protein-protein interaction domain, it has recently been shown that certain SAM domains have the ability to bind RNA, defining a new type of post-transcriptional gene regulator. To further understand the function of SAM-RNA recognition, we determined the solution structures of the SAM domain of the Saccharomyces cerevisiae Vts1p (Vts1p-SAM) and the Smaug response element (SRE) stem-loop RNA as a complex and in isolation. The structures show that Vts1p-SAM recognizes predominantly the shape of the SRE rather than its sequence, with the exception of a G located at the tip of the pentaloop. Using microarray gene profiling, we identified several genes in S. cerevisiae that seem to be regulated by Vts1p and contain one or more copies of the SRE.
+The line below this paragraph, {{ABSTRACT_PUBMED_16429156}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16429156 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16429156}}
 ==About this Structure==
-Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ES5 OCA].
+Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ES5 OCA].
 ==Reference==
@@ Line 24: / Line 28: @@
 [[Category: Rna structure]]
 [[Category: Stem-loop]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 03:03:19 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:51:52 2008''