2ese: Difference between revisions

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[[Image:2ese.gif|left|200px]]
{{Seed}}
[[Image:2ese.png|left|200px]]


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{{STRUCTURE_2ese|  PDB=2ese  |  SCENE=  }}  
{{STRUCTURE_2ese|  PDB=2ese  |  SCENE=  }}  


'''Structure of the SAM domain of Vts1p in complex with RNA'''
===Structure of the SAM domain of Vts1p in complex with RNA===




==Overview==
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Although the abundant sterile alpha motif (SAM) domain was originally classified as a protein-protein interaction domain, it has recently been shown that certain SAM domains have the ability to bind RNA, defining a new type of post-transcriptional gene regulator. To further understand the function of SAM-RNA recognition, we determined the solution structures of the SAM domain of the Saccharomyces cerevisiae Vts1p (Vts1p-SAM) and the Smaug response element (SRE) stem-loop RNA as a complex and in isolation. The structures show that Vts1p-SAM recognizes predominantly the shape of the SRE rather than its sequence, with the exception of a G located at the tip of the pentaloop. Using microarray gene profiling, we identified several genes in S. cerevisiae that seem to be regulated by Vts1p and contain one or more copies of the SRE.
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{{ABSTRACT_PUBMED_16429156}}


==About this Structure==
==About this Structure==
2ESE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ESE OCA].  
2ESE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ESE OCA].  


==Reference==
==Reference==
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[[Category: Shape specific recognition]]
[[Category: Shape specific recognition]]
[[Category: Stem-loop]]
[[Category: Stem-loop]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 03:03:51 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:50:21 2008''

Revision as of 05:50, 29 July 2008

File:2ese.png

Template:STRUCTURE 2ese

Structure of the SAM domain of Vts1p in complex with RNA

Template:ABSTRACT PUBMED 16429156

About this Structure

2ESE is a Single protein structure of sequence from Saccharomyces cerevisiae. Full experimental information is available from OCA.

Reference

Shape-specific recognition in the structure of the Vts1p SAM domain with RNA., Oberstrass FC, Lee A, Stefl R, Janis M, Chanfreau G, Allain FH, Nat Struct Mol Biol. 2006 Feb;13(2):160-7. Epub 2006 Jan 22. PMID:16429156

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