2icw: Difference between revisions

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[[Image:2icw.gif|left|200px]]<br />

[[Image:2icw.gif|left|200px]]<br /><applet load="2icw" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="2icw" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="2icw, resolution 2.410Å" />

'''Crystal structure of a complete ternary complex between TCR, superantigen, and peptide-MHC class II molecule'''<br />

==Overview==

'Superantigens' (SAgs) trigger the massive activation of T cells by, simultaneous interactions with MHC and TCR receptors, leading to human, diseases. Here we present the first crystal structure, at 2.5-A, resolution, of a complete ternary complex between a SAg and its two, receptors, HLA-DR1/HA and TCR. The most striking finding is that the SAg, Mycoplasma arthritidis mitogen, unlike others, has direct contacts not, only with TCR Vbeta but with TCR Valpha.

'Superantigens' (SAgs) trigger the massive activation of T cells by simultaneous interactions with MHC and TCR receptors, leading to human diseases. Here we present the first crystal structure, at 2.5-A resolution, of a complete ternary complex between a SAg and its two receptors, HLA-DR1/HA and TCR. The most striking finding is that the SAg Mycoplasma arthritidis mitogen, unlike others, has direct contacts not only with TCR Vbeta but with TCR Valpha.

==About this Structure==

2ICW is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Mycoplasma_arthritidis Mycoplasma arthritidis]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=2ICW OCA].

2ICW is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Mycoplasma_arthritidis Mycoplasma arthritidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ICW OCA].

==Reference==

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[[Category: tcr]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov 12 22~~:43:~~40 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:51:22 2008''

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@@ Line 1: / Line 1: @@
-[[Image:2icw.gif|left|200px]]<br />
+[[Image:2icw.gif|left|200px]]<br /><applet load="2icw" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="2icw" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="2icw, resolution 2.410&Aring;" />
 '''Crystal structure of a complete ternary complex between TCR, superantigen, and peptide-MHC class II molecule'''<br />
 ==Overview==
-'Superantigens' (SAgs) trigger the massive activation of T cells by, simultaneous interactions with MHC and TCR receptors, leading to human, diseases. Here we present the first crystal structure, at 2.5-A, resolution, of a complete ternary complex between a SAg and its two, receptors, HLA-DR1/HA and TCR. The most striking finding is that the SAg, Mycoplasma arthritidis mitogen, unlike others, has direct contacts not, only with TCR Vbeta but with TCR Valpha.
+'Superantigens' (SAgs) trigger the massive activation of T cells by simultaneous interactions with MHC and TCR receptors, leading to human diseases. Here we present the first crystal structure, at 2.5-A resolution, of a complete ternary complex between a SAg and its two receptors, HLA-DR1/HA and TCR. The most striking finding is that the SAg Mycoplasma arthritidis mitogen, unlike others, has direct contacts not only with TCR Vbeta but with TCR Valpha.
 ==About this Structure==
-ICW is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Mycoplasma_arthritidis Mycoplasma arthritidis]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2ICW OCA].
+ICW is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Mycoplasma_arthritidis Mycoplasma arthritidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ICW OCA].
 ==Reference==
@@ Line 24: / Line 23: @@
 [[Category: tcr]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 22:43:40 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:51:22 2008''