2ig2: Difference between revisions

Line 1:

[[Image:2ig2.gif|left|200px]]<br />

[[Image:2ig2.gif|left|200px]]<br /><applet load="2ig2" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="2ig2" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="2ig2, resolution 3.0Å" />

'''DIR PRIMAERSTRUKTUR DES KRISTALLISIERBAREN MONOKLONALEN IMMUNOGLOBULINS IGG1 KOL. II. AMINOSAEURESEQUENZ DER L-KETTE, LAMBDA-TYP, SUBGRUPPE I (GERMAN)'''<br />

==Overview==

The immunoglobulin Kol was the first intact antibody molecule which was, characterized by high-resolution X-ray crystallography. Furthermore the, complete amino-acid sequence of the heavy (H)-chain is known. Here we, report the complete amino-acid sequence of the light (L)-chain of the, monoclonal immunoglobulin Kol (IgG1). The polypeptide has an Mr of 22,781, consists of 216 amino acids and due to its structure is of the, lambda-type. With the characteristic amino acids threonine, asparagine, threonine, glycine and lysine in positions 101, 114, 116, 154, and 165, respectively the Kol L-chain is of the Mcg isotype. With the proteins Mcg, Mot, Bur, Loc and Mem six myeloma-derived amino-acid sequences of the same, isotype are known. The amino-acid sequence of the N-terminal variable part, is characteristic of subgroup 1. This contribution completes the primary, structure of IgG1 Kol.

The immunoglobulin Kol was the first intact antibody molecule which was characterized by high-resolution X-ray crystallography. Furthermore the complete amino-acid sequence of the heavy (H)-chain is known. Here we report the complete amino-acid sequence of the light (L)-chain of the monoclonal immunoglobulin Kol (IgG1). The polypeptide has an Mr of 22,781, consists of 216 amino acids and due to its structure is of the lambda-type. With the characteristic amino acids threonine, asparagine, threonine, glycine and lysine in positions 101, 114, 116, 154, and 165, respectively the Kol L-chain is of the Mcg isotype. With the proteins Mcg, Mot, Bur, Loc and Mem six myeloma-derived amino-acid sequences of the same isotype are known. The amino-acid sequence of the N-terminal variable part is characteristic of subgroup 1. This contribution completes the primary structure of IgG1 Kol.

==About this Structure==

2IG2 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure ~~superseeds~~ the now removed PDB entry 1IG2. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=2IG2 OCA].

2IG2 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry 1IG2. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IG2 OCA].

==Reference==

Line 18:

Line 17:

[[Category: immunoglobulin]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov 12 22~~:44:~~23 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:52:24 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:2ig2.gif|left|200px]]<br />
+[[Image:2ig2.gif|left|200px]]<br /><applet load="2ig2" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="2ig2" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="2ig2, resolution 3.0&Aring;" />
 '''DIR PRIMAERSTRUKTUR DES KRISTALLISIERBAREN MONOKLONALEN IMMUNOGLOBULINS IGG1 KOL. II. AMINOSAEURESEQUENZ DER L-KETTE, LAMBDA-TYP, SUBGRUPPE I (GERMAN)'''<br />
 ==Overview==
-The immunoglobulin Kol was the first intact antibody molecule which was, characterized by high-resolution X-ray crystallography. Furthermore the, complete amino-acid sequence of the heavy (H)-chain is known. Here we, report the complete amino-acid sequence of the light (L)-chain of the, monoclonal immunoglobulin Kol (IgG1). The polypeptide has an Mr of 22,781, consists of 216 amino acids and due to its structure is of the, lambda-type. With the characteristic amino acids threonine, asparagine, threonine, glycine and lysine in positions 101, 114, 116, 154, and 165, respectively the Kol L-chain is of the Mcg isotype. With the proteins Mcg, Mot, Bur, Loc and Mem six myeloma-derived amino-acid sequences of the same, isotype are known. The amino-acid sequence of the N-terminal variable part, is characteristic of subgroup 1. This contribution completes the primary, structure of IgG1 Kol.
+The immunoglobulin Kol was the first intact antibody molecule which was characterized by high-resolution X-ray crystallography. Furthermore the complete amino-acid sequence of the heavy (H)-chain is known. Here we report the complete amino-acid sequence of the light (L)-chain of the monoclonal immunoglobulin Kol (IgG1). The polypeptide has an Mr of 22,781, consists of 216 amino acids and due to its structure is of the lambda-type. With the characteristic amino acids threonine, asparagine, threonine, glycine and lysine in positions 101, 114, 116, 154, and 165, respectively the Kol L-chain is of the Mcg isotype. With the proteins Mcg, Mot, Bur, Loc and Mem six myeloma-derived amino-acid sequences of the same isotype are known. The amino-acid sequence of the N-terminal variable part is characteristic of subgroup 1. This contribution completes the primary structure of IgG1 Kol.
 ==About this Structure==
-IG2 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure superseeds the now removed PDB entry 1IG2. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2IG2 OCA].
+IG2 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry 1IG2. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IG2 OCA].
 ==Reference==
@@ Line 18: / Line 17: @@
 [[Category: immunoglobulin]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 22:44:23 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:52:24 2008''