2f2h: Difference between revisions

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[[Image:2f2h.gif|left|200px]]
{{Seed}}
[[Image:2f2h.png|left|200px]]


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{{STRUCTURE_2f2h|  PDB=2f2h  |  SCENE=  }}  
{{STRUCTURE_2f2h|  PDB=2f2h  |  SCENE=  }}  


'''Structure of the YicI thiosugar Michaelis complex'''
===Structure of the YicI thiosugar Michaelis complex===




==Overview==
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For the first time, the thioglycoligase strategy has been successfully applied to alpha-glycosidases. The alpha-thioglycoligases derived from the family 31 glycosidases, alpha-xylosidase from E. coli (YicI) and alpha-glucosidase from Sulfolobus solfataricus, catalyze thioglycoligase reactions using alpha-glycosyl fluorides and deoxythioglycosides as donors and acceptors, respectively, in yields up to 86%. In addition, we describe the Michaelis complex of YicI using one of the thioglycosides as a nonhydrolyzable substrate analogue and discuss the structural insights this yields into the specificity and mechanism of family 31 alpha-glycosidases and the molecular basis of an associated genetic disease.
The line below this paragraph, {{ABSTRACT_PUBMED_16478160}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_16478160}}


==About this Structure==
==About this Structure==
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[[Category: Withers, S G.]]
[[Category: Withers, S G.]]
[[Category: Beta8alpha8 barrel]]
[[Category: Beta8alpha8 barrel]]
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