2f3z: Difference between revisions

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[[Image:2f3z.gif|left|200px]]
{{Seed}}
[[Image:2f3z.png|left|200px]]


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{{STRUCTURE_2f3z|  PDB=2f3z  |  SCENE=  }}  
{{STRUCTURE_2f3z|  PDB=2f3z  |  SCENE=  }}  


'''Calmodulin/IQ-AA domain complex'''
===Calmodulin/IQ-AA domain complex===




==Overview==
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Ca2+-dependent inactivation (CDI) and facilitation (CDF) of the Ca(v)1.2 Ca2+ channel require calmodulin binding to a putative IQ motif in the carboxy-terminal tail of the pore-forming subunit. We present the 1.45 A crystal structure of Ca2+-calmodulin bound to a 21 residue peptide corresponding to the IQ domain of Ca(v)1.2. This structure shows that parallel binding of calmodulin to the IQ domain is governed by hydrophobic interactions. Mutations of residues I1672 and Q1673 in the peptide to alanines, which abolish CDI but not CDF in the channel, do not greatly alter the structure. Both lobes of Ca2+-saturated CaM bind to the IQ peptide but isoleucine 1672, thought to form an intramolecular interaction that drives CDI, is buried. These findings suggest that this structure could represent the conformation that calmodulin assumes in CDF.
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{{ABSTRACT_PUBMED_16338416}}


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Structure of calmodulin bound to the hydrophobic IQ domain of the cardiac Ca(v)1.2 calcium channel., Fallon JL, Halling DB, Hamilton SL, Quiocho FA, Structure. 2005 Dec;13(12):1881-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16338416 16338416]
Structure of calmodulin bound to the hydrophobic IQ domain of the cardiac Ca(v)1.2 calcium channel., Fallon JL, Halling DB, Hamilton SL, Quiocho FA, Structure. 2005 Dec;13(12):1881-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16338416 16338416]
Target enzyme recognition by calmodulin: 2.4 A structure of a calmodulin-peptide complex., Meador WE, Means AR, Quiocho FA, Science. 1992 Aug 28;257(5074):1251-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1519061 1519061]
A closed compact structure of native Ca(2+)-calmodulin., Fallon JL, Quiocho FA, Structure. 2003 Oct;11(10):1303-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14527397 14527397]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: Iq domain]]
[[Category: Iq domain]]
[[Category: Iq-aa mutant domain]]
[[Category: Iq-aa mutant domain]]
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